Synthesis and Antibacterial Evaluation of 2-(chloro / ethyl thio / seleno)-1,8-naphthyridine-3-azetidine Derivatives

Synthesis of new heterocyclic fuse compounds by reaction of N-acetyl-2-amino pyridine with through Vilsmeier-Haack cyclization to give 2-chloro-3-formyl-1,8-naphthyridine (1) , chloro atom changing with selenium (2) or Et-Sgroup (3) , the formyl group in the compounds (1,2,3) converted to schiff base by react with aryl amine (4-9), shiff base derivatives reaction with chloroacetylchloride in triethylamine to give azetidine ring (10-15) . The structures of synthesized compounds were confirmed by spectral and physical data. Some of the newly synthesized compounds exhibited antibacterial activity.