Evaluation of prenatal invasive procedures: analysis of retrospective cases

Objective: In this study, we aimed to present the results of prenatal invasive procedures carried out in our clinic. Methods: The records of the prenatal invasive procedures carried out between April 2011 and 2014 were analyzed retrospectively, and the indications, complications and karyotype results of invasive procedures were evaluated. Results: Prenatal invasive procedure was applied to 72 (23.4%) pregnant women who had only minor and/or major anomalies according to ultrasonography, 226 (73.3%) patients who referred for increased risk at screening tests, 5 (1.6%) patients with family history and 5 (1.6%) patients with advanced maternal age. Amniocentesis was carried out for 81.8% (n=252) of these patients, chorionic villus sampling for 11.7% (n=36) of them, and cordocentesis due to advanced week of gestation for 6.5% (n=20) of them. Karyotype analysis results were normal in 278 (90.2%) patients but no cytogenetic result was obtained in 11 (3.5%) patient, and aneuploidy was reported in 19 (6.2%) patients (trisomy in 2.9% and other genetic anomalies / variations in 3.3%). Two patients with karyotype results as 46XX+22p and 46XY,9qh were followed up. The results of the patients whose ultrasonography examination did not show any minor marker or major anomaly were considered as normal variants. Such pregnancies resulted in healthy live births. Karyotype anomalies also having ultrasonography findings were terminated. Conclusion: Prenatal screening tests are still the major indications for prenatal invasive procedures. However, minor and/or major anomalies can be displayed in most of the aneuploidic fetuses; therefore, fetuses established with prenatal diagnosis indication should be evaluated carefully.