The role of the first trimester inflammation markers at early and late preeclampsia

Objective: Our aim was to compare the difference between the levels of first trimester neutrophil/lymphocyte rate (NLR), platelet/lymphocyte rate (PLR), red blood distribution width (RDW), mean platelet volume (MPV) in patients developing earlyonset or late-onset preeclampsia during their pregnancies. Methods: In our clinic, 118 patients diagnosed as preeclampsia were evaluated retrospectively. The patients were separated into two groups as early-onset and late-onset preeclampsia. First trimester laboratory data were collected and the two groups were evaluated in terms of inflammation markers. Results: No significant difference was found among two groups in terms of inflammation markers. Birth week, mean birth weight and mean newborn percentile values (33.12±3.05 weeks, 1703±640 g and 11.15±15.54 percentile, respectively) of early preeclampsia group were found to be significantly lower than the late preeclampsia group (37.42±1.50 weeks, 2760±580 g and 29.16±30.36 percentile, respectively; p<0.001, p<0.001, p=0.002). The rate for delivery by cesarean section and the incidence for baby with growth retardation in the early preeclampsia group (100% and 64%, respectively) was significantly higher than the late preeclampsia group (86% and 37%, respectively; p=0.024, p=0.018). Conclusion: High rate of growth retardation in early preeclampsia brings to mind that a placental pathology has a significant role in this group. We found no difference when we evaluate the systemic reflection of this pathology in terms of the inflammation markers in early weeks of gestation.