Cordocentesis outcomes of tertiary care services in Manisa city: a retrospective analysis of four years

Objective: It is aimed to evaluate the outcomes of cordocentesis interventions performed for karyotyping in our clinic between 2009 and 2012. Methods: The data of 59 patients who had cordocentesis for genetic analysis due to various indications between 2009 and 2012 were analyzed retrospectively. Results: Out of 59 patients, the tissue culture was successful in 52 cases. The culture success rate in cordocentesis was detected as 88.1%. The mean week of gestation at the cordocentesis period was 26.55±3.75. Out of the 52 cases with successful tissue culture, chromosomal disorders were detected in 11.5% (6/52 cases). Ventriculomegaly was the most common indication of cordocentesis (24/59). The second most common indication was neural tube defect found in 11 cases (18.6%). The other indications were hydrops fetalis (13.6%), skeletal dysplasia (11.9%), and cardiac anomalies (8.5%). There was no complication following cordocentesis. Conclusion: Cordocentesis has been commonly performed with the use of high-resolution ultrasonography devices. It can be applied from 18 weeks of gestation until term gestation. Cordocentesis should be preferred especially for the pregnancies admitted during late gestations and needed rapid results of karyotyping. It must be kept in mind that the risk of fetal demise is approximately 1.2-4.9% following the procedure and the success of cordocentesis varies between 85 and 98.4% depending on the experience of the clinician.