The roles of endothelial nitric oxide synthase (eNOS) and myeloperoxidase (MPO) genes in microtia | Zendy

Berker Büyükgüral | Zendy; Sacide Pehlıvan | Zendy; Ayşe Feyda Nursal | Zendy; Mehmet Bekerecioğlu | Zendy

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The roles of endothelial nitric oxide synthase (eNOS) and myeloperoxidase (MPO) genes in microtia

Author(s) -

Berker Büyükgüral,

Sacide Pehlıvan,

Ayşe Feyda Nursal,

Mehmet Bekerecioğlu

Publication year - 2016

Publication title -

ent updates

Language(s) - Turkish

Resource type - Journals

ISSN - 2149-7109

DOI - 10.2399/jmu.2016003008

Subject(s) - myeloperoxidase , enos , endothelial nitric oxide synthase , nitric oxide , nitric oxide synthase , chemistry , biochemistry , biology , medicine , inflammation

Yöntem: Çal›flmaya akraba olmayan 19 (11 erkek, 8 kad›n) mikrotiyal› olgu ve 40 sa¤l›kl› kontrol al›nd›. Çal›flma, ekson 7’nin bir varyant› (G894T), eNOS geninin 4. nitronunda (VNTR) de¤iflken say›da 27 bp ard›fl›k tekrarlar ve MPO geninin promoter bölgesinde (G463A) bir varyant olmak üzere üç fonksiyonel varyant üzerine odakland›. Polimeraz zincir reaksiyonu (PCR) ve/veya PCR-restriksiyon parça uzunluk polimorfizm (RFLP) yöntemi kullanarak bu varyantlar›n genotiplerini ç›kard›k. Ki-kare testi kullanarak mikrotiya olgular›yla sa¤l›kl› kontroller aras›nda eNOS ve MPO genlerinde alel ve genotip da¤›l›m›n› karfl›laflt›rd›k.

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