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Yöntem: Çal›flmaya akraba olmayan 19 (11 erkek, 8 kad›n) mikrotiyal› olgu ve 40 sa¤l›kl› kontrol al›nd›. Çal›flma, ekson 7’nin bir varyant› (G894T), eNOS geninin 4. nitronunda (VNTR) de¤iflken say›da 27 bp ard›fl›k tekrarlar ve MPO geninin promoter bölgesinde (G463A) bir varyant olmak üzere üç fonksiyonel varyant üzerine odakland›. Polimeraz zincir reaksiyonu (PCR) ve/veya PCR-restriksiyon parça uzunluk polimorfizm (RFLP) yöntemi kullanarak bu varyantlar›n genotiplerini ç›kard›k. Ki-kare testi kullanarak mikrotiya olgular›yla sa¤l›kl› kontroller aras›nda eNOS ve MPO genlerinde alel ve genotip da¤›l›m›n› karfl›laflt›rd›k.

The roles of endothelial nitric oxide synthase (eNOS) and myeloperoxidase (MPO) genes in microtia