Evaluation of mean platelet volume and neutrophil to lymphocyte ratio as a diagnostic indicator in patients with recurrent aphthous stomatitis

Recurrent aphthous stomatitis (RAS) is an inflammatory disease of the oral mucosa characterized by painful, multiple, well-defined lesions with a necrotic center surrounded by erythematous halo, observed especially in children and adolescents. The etiopathogenesis of RAS is not fully known, but is accepted as idiopathic or multifactorial. Among etiological factors genetic, immunological, hormonal, nutritional or hematological deficiencies and some environmental causes (trauma, stress, medications, and microorganisms) are blamed. Mean platelet volume (MPV) in full blood counts provides information on the size and activity of platelets and is evaluated as a marker of platelet dysfunction. Larger platelets are more active and prone to aggregation and