The influence of iris color and retina pigment epithelium melanin on allergic rhinitis

Allergic rhinitis is an increasingly common disorder which manifests itself with symptoms of itchy nose, rhinorrhea, sneezing and nasal congestion as a result of exposure of sensitized individuals to certain antigens. The release of vasoactive mediators such as histamine, leukotrienes, prostaglandins, cytokines and tryptase follows after allergens bind specific IgE on the surfaces of basophils and mast cells and they show their effects in nasal vasculature by their receptors to result in either vasoconstriction and vasodilatation. Alterations in vascular innervation can be one of the reasons in regards of the continuity of allergic rhinitis. Normally, a constant release of noradrenaline is thought to Clinical Research