Partial corpus callosum agenesis and colpocephaly: a case report

Callosal abnormalities are mostly described as central nervous system malformations and can be symptomatic or asymptomatic.  Herein, we report an autopsy case of a 50-year-old Syrian immigrant male with poor academic performance, presented  with partial agenesis of the corpus callosum and colpocephaly. He was evidently asymptomatic until death.The cause  of death was determined to be hypothermia. Autosy revealed a corpus callosum of 3 cm only in the anterior part. Posterior  part of the corpus callosum, anterior, posterior and hippocampal commissures were absent. On coronal sections, inferior  horn of the lateral ventricle was dilated. Histopathological examination showed petechial microhemorrhagic areas and congestion  in the brain. This case report was presented to demonstrate a good example of corpus callosum agenesis in asymptomatic  individuals except for poor academic performance. Furthermore, this is the first corpus callosum agenesis in medical  literature encountered during medicolegal autopsy in an adult case.