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Three simple, sensitive, selective, accurate and efficient spectrophotometric methods for determining cefixime in bulk drug and pharmaceutical formulations have described. The first method involved conversion of NH 2 in cefixime to diazonium salt, which has coupled with Bisphenol A in an alkaline medium. The orange colored product showed λ max at 490 nm and followed Beer's law over a concentration range of 1-50 μg mL -1 , with molar absorptivity of 0.866×10 4 L.mol -1 .cm -1 and the detection limit was 0.157 μg.mL -1 . The second method involved pre-concentration of a trace amount of cefixime-azo dyes using cloud point extraction (CPE). The extracted drug- dye was spectrophotometrically measured at λ max 500. The constructed calibration curve to determine cefixime followed Beer’s law in a range of 0.25-6 μg.mL -1 , with a correlation coefficient of 0.9998, molar absorptivity of 0.961×10 5 L.mol -1 .cm -1 and the detection limit was equal to 0.031 μg.mL -1 . The pre-concentration factor was 25 and distribution coefficient (D) was 314.03. A diazotization of the studied drug (cefixime) and its coupling with Bisphenol A was studied using a developed flow injection analysis method, based on the detection of the absorption of the diazotization product. Chemical and physical properties [of what??] were studied to develop the suggested method and to determine the stability of the colored of product. A flow rate of 2.5 mL.min -1 , 50 cm reaction coil and 100 μL sample volume were used to operate the system and the orange colored product was detected at 490 nm. The proposed three methods were successfully applied to determine cefixime in pharmaceutical formulation, where results were satisfactory

Determination of Cefixime Using Batch, Cloud Point Extraction and Flow Injection as New Spectrophotometric Methods