Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique | Zendy

Faiq H. Saaid | Zendy; Shatha J. Dawood | Zendy; Bushra H. Marbeen | Zendy

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Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique

Author(s) -

Faiq H. Saaid,

Shatha J. Dawood,

Bushra H. Marbeen

Publication year - 2018

Publication title -

al-mustansiriyah journal of science

Language(s) - English

Resource type - Journals

eISSN - 2521-3520

pISSN - 1814-635X

DOI - 10.23851/mjs.v29i2.183

Subject(s) - chloroacetic acid , hydrazine (antidepressant) , solvent , ultrasonic sensor , chemistry , diamine , nuclear chemistry , organic chemistry , chromatography , medicine , radiology

In the present study, a new of 1,3,4-oxadizole derivatives(4a1,4a2,4b1,4b2) were synthesized using an ultrasonic technique. Benzohydrazine and its substituted (2a, 2b) were obtained from the reaction of hydrazin with benzoylchloride and its substituted (1a, 1b). Compounds (2a, 2b) react with chloroacetic acid to form compounds (3a,3b) which react with p-phenylene diamine and hydrazine in presence of DMSO as a solvent to obtain new compounds (4a1,4a2, 4b1,4b2) by ultrasonic technique. The structures of the synthesized compounds were elucidated by spectral data: infrared spectra (FT-IR) and 1HNMR and CHN analysis. The synthesis compounds (4b1, 4b2, 4a1, and 4a2) were evaluated for antibacterial (Staphylococcus1 aureus) by the serial dilution method

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