Inactivation of Matrix-bound Matrix Metalloproteinases by Cross-linking Agents in Acid-etched Dentin | Zendy

Débora Lopes Salles Scheffel | Zendy; Josimeri Hebling | Zendy; R.H. Scheffel | Zendy; Kelli A. Agee | Zendy; Gianluca Turco | Zendy; Carlos Alberto de Souza Costa | Zendy; D.H. Pashley | Zendy

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Inactivation of Matrix-bound Matrix Metalloproteinases by Cross-linking Agents in Acid-etched Dentin

Author(s) -

Débora Lopes Salles Scheffel,

Josimeri Hebling,

R.H. Scheffel,

Kelli A. Agee,

Gianluca Turco,

Carlos Alberto de Souza Costa,

D.H. Pashley

Publication year - 2013

Publication title -

operative dentistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.965

H-Index - 81

eISSN - 1559-2863

pISSN - 0361-7734

DOI - 10.2341/12-425-l

Subject(s) - dentin , molar , matrix metalloproteinase , chemistry , methacrylate , phosphoric acid , nuclear chemistry , absorbance , matrix (chemical analysis) , dentistry , materials science , chromatography , composite material , biochemistry , polymer , organic chemistry , copolymer , medicine

Published transmission electron microscopy analysis of in vitro resin-dentin bonds shows that, after 44 months, almost 70% of collagen fibrils from the hybrid layer disappear. Matrix metalloproteinases (MMPs) play an important role in that process and are thought to be the main factor responsible for the solubilization of dentin collagen. Therefore, this study aimed to evaluate the inactivation of matrix-bound MMPs by two different cross-linking agents, carbodiimide (EDC) or proanthocyanidin (PA), or the MMP-inhibitor, chlorhexidine (CHX), on acid-etched dentin using a simplified MMP assay method.

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