Polycystic Ovary Syndrome and Pregnancy: Is Metformin the Magic Bullet? | Zendy

Howard Zisser | Zendy

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Polycystic Ovary Syndrome and Pregnancy: Is Metformin the Magic Bullet?

Author(s) -

Howard Zisser

Publication year - 2007

Publication title -

diabetes spectrum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.716

H-Index - 31

eISSN - 1944-7353

pISSN - 1040-9165

DOI - 10.2337/diaspect.20.2.85

Subject(s) - medicine , metformin , polycystic ovary , pregnancy , gestational diabetes , magic bullet , population , diabetes mellitus , weight loss , obstetrics , gynecology , endocrinology , insulin resistance , gestation , bioinformatics , obesity , environmental health , biology , genetics

In Brief This article reviews the literature regarding the effects of metformintherapy in pregnant women with polycystic ovary syndrome on weight loss,fertility, early pregnancy loss, malformations, gestational diabetes mellitus,perinatal mortality, placental clearance, lactation, and early childhooddevelopment. The pharmacology of metformin is also presented. Preliminary datasuggest that metformin for this population may be both safe and effective.Large blinded, randomized clinical trials are underway to confirm thepreliminary safety data.

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