SGLT-2 Inhibitors: A New Mechanism for Glycemic Control | Zendy

Edward C. Chao | Zendy

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SGLT-2 Inhibitors: A New Mechanism for Glycemic Control

Author(s) -

Edward C. Chao

Publication year - 2014

Publication title -

clinical diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.931

H-Index - 37

eISSN - 1945-4953

pISSN - 0891-8929

DOI - 10.2337/diaclin.32.1.4

Subject(s) - medicine , glycemic , mechanism (biology) , diabetes mellitus , renal glucose reabsorption , pharmacology , type 2 diabetes , endocrinology , bioinformatics , philosophy , epistemology , biology

Glucosuria, the presence of glucose in the urine, has long been regarded as a consequence of uncontrolled diabetes. However, glucose excretion can be induced by blocking the activity of the renal sodium-glucose cotransporter 2 (SGLT-2). This mechanism corrects hyperglycemia independently of insulin. This article provides an overview of the paradigm shift that triggered the development of the SGLT-2 inhibitor class of agents and summarizes the available evidence from clinical studies to date.

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