Effects of Oral Fat Load on Insulin Output and Glucose Tolerance in Healthy Control Subjects and Obese Patients Without Diabetes | Zendy

Oliver Wuesten | Zendy; Cristoph H. Balz | Zendy; Reinhard G. Bretzel | Zendy; Hans-Ulrich Kloer | Zendy; Philip D. Hardt | Zendy

Open Access

Effects of Oral Fat Load on Insulin Output and Glucose Tolerance in Healthy Control Subjects and Obese Patients Without Diabetes

Author(s) -

Oliver Wuesten,

Cristoph H. Balz,

Reinhard G. Bretzel,

Hans-Ulrich Kloer,

Philip D. Hardt

Publication year - 2005

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/diacare.28.2.360

Subject(s) - nefa , medicine , endocrinology , insulin , hyperinsulinemia , diabetes mellitus , insulin resistance , type 2 diabetes , impaired glucose tolerance , glucose tolerance test , carbohydrate metabolism

Elevated plasma nonesterified fatty acid (NEFA) concentrations cause peripheral and hepatic insulin resistance and may play an important role in regulating glucose-induced insulin secretion. The aim of our study was to investigate the influence of physiologically elevated NEFA levels on glucose-stimulated insulin secretion in order to find evidence that NEFAs are a potential factor predisposing for type 2 diabetes and related metabolic disorders, which are known risk factors for cardiovascular disease.

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