Left Ventricular Mass Increases With Deteriorating Glucose Tolerance, Especially in Women: Independence of Increased Arterial Stiffness or Decreased Flow-Mediated Dilation | Zendy

Ronald M.A. Henry | Zendy; Otto Kamp | Zendy; Piet J. Kostense | Zendy; Annemieke M. W. Spijkerman | Zendy; Joost Dekker | Zendy; Rosemarie van Eijck | Zendy; Giel Nijpels | Zendy; Robert J. Heine | Zendy; L.M. Bouter | Zendy; Coen D.A. Stehouwer | Zendy

Open Access

Left Ventricular Mass Increases With Deteriorating Glucose Tolerance, Especially in Women: Independence of Increased Arterial Stiffness or Decreased Flow-Mediated Dilation

Author(s) -

Ronald M.A. Henry,

Otto Kamp,

Piet J. Kostense,

Annemieke M. W. Spijkerman,

Joost Dekker,

Rosemarie van Eijck,

Giel Nijpels,

Robert J. Heine,

L.M. Bouter,

Coen D.A. Stehouwer

Publication year - 2004

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/diacare.27.2.522

Subject(s) - medicine , arterial stiffness , diabetes mellitus , type 2 diabetes , endocrinology , cardiology , pulse wave velocity , impaired glucose tolerance , insulin resistance , body mass index , population , endothelial dysfunction , vascular resistance , blood pressure , pathogenesis , environmental health

Type 2 diabetes and impaired glucose metabolism (IGM) are associated with an increased cardiovascular disease (CVD) risk. Increased left ventricular mass (LVM) is thought to increase CVD risk through several unfavorable cardiac changes. Type 2 diabetes and IGM are associated with increased LVM, but the underlying mechanism is unclear. We investigated the association between glucose tolerance status (GTS) and LVM and explored whether any such association could be mediated through increased arterial stiffness, impaired endothelial function, or the presence of atherosclerosis.

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