Open AccessRelation Between Development of Nephropathy and the p22phox C242T and Receptor for Advanced Glycation End Product G1704T Gene Polymorphisms in Type 2 Diabetic Patients
Author(s) -
Seiko Matsunaga-Irie,
Taro Maruyama,
Y. Yamamoto,
Yoshiko Motohashi,
Hiroshi Hirose,
Akira Shimada,
Mitsuru Murata,
Takao Saruta
Publication year - 2004
Publication title -
diabetes care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.636
H-Index - 363
eISSN - 1935-5548
pISSN - 0149-5992
DOI - 10.2337/diacare.27.2.303
Subject(s) - p22phox , medicine , nephropathy , diabetic nephropathy , glycation , advanced glycation end product , endocrinology , diabetes mellitus , genotype , type 2 diabetes , nadph oxidase , rage (emotion) , oxidative stress , biology , genetics , gene , neuroscience
The development of diabetic nephropathy is considered to be associated with oxidative stress. NADPH oxidase and the receptor for advanced glycation end products (RAGE) have attracted attention as mechanisms of generating oxidative stress. We studied the relation between the genotypes of the NADPH p22phox C242T and RAGE G1704T polymorphisms and the development of diabetic nephropathy in type 2 diabetic patients.
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