Identification of a Simple Tandem Repeat DNA Polymorphism in the Human Glycogen Synthase Gene and Linkage to Five Markers on Chromosome 19q | Zendy

Nathalie Vionnet | Zendy; G.I. Bell | Zendy

Open Access

Identification of a Simple Tandem Repeat DNA Polymorphism in the Human Glycogen Synthase Gene and Linkage to Five Markers on Chromosome 19q

Author(s) -

Nathalie Vionnet,

G.I. Bell

Publication year - 1993

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/diab.42.6.930

Subject(s) - biology , genetics , loss of heterozygosity , gene , glycogen synthase , microbiology and biotechnology , allele , genetic marker , phosphorylation

We have identified a simple tandem repeat DNA polymorphism in the human glycogen synthase gene of the form (TG)n. This DNA polymorphism has 10 alleles and a heterozygosity of 0.82 and can be easily typed using the polymerase chain reaction. It has been localized within the framework genetic map of chromosome 19 and is located in the region of the apolipoprotein C-II and histidine-rich calcium-binding protein genes. This DNA polymorphism will facilitate genetic studies of the role of the glycogen synthase gene in the development of insulin resistance and NIDDM.

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