Genetics of Autoimmune Thyroiditis in Type 1 Diabetes Reveals a Novel Association With DPB1*0201: Data From the Type 1 Diabetes Genetics Consortium | Zendy

Heinrich Kahles | Zendy; Pamela R. Fain | Zendy; Peter R. Baker | Zendy; George S. Eisenbarth | Zendy; Klaus Badenhoop | Zendy

Open Access

Genetics of Autoimmune Thyroiditis in Type 1 Diabetes Reveals a Novel Association With DPB1*0201: Data From the Type 1 Diabetes Genetics Consortium

Author(s) -

Heinrich Kahles,

Pamela R. Fain,

Peter R. Baker,

George S. Eisenbarth,

Klaus Badenhoop

Publication year - 2015

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dcs15-2005

Subject(s) - medicine , type 1 diabetes , genetics , diabetes mellitus , type 2 diabetes , thyroiditis , genome wide association study , autoimmune thyroiditis , human genetics , immunology , disease , gene , single nucleotide polymorphism , endocrinology , biology , genotype

Autoimmune thyroiditis occurs in 10-25% of patients with type 1 diabetes (T1D). Most of these patients are also positive for thyroid peroxidase (TPO) antibodies. Thyroid dysfunction complicates T1D metabolic control and is a component of the autoimmune polyglandular syndrome (APS, type 2 or 3). Previous studies of isolated T1D and of T1D combined with other autoimmune disorders showed genetic susceptibility for alleles in HLA-DQB1 and -DRB1 and also CTLA4 and PTPN22.

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