Open AccessFinerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study
Author(s) -
Peter Rossing,
Ellen Burgess,
Rajiv Agarwal,
Stefan D. Anker,
Gerasimos Filippatos,
Bertram Pitt,
Luís M. Ruilope,
Pieter Gillard,
Richard J. MacIsaac,
Julio Wainstein,
Amer Joseph,
Meike Brinker,
Lothar Roessig,
Charlie Scott,
George L. Bakris,
Augusto Vallejos,
Guntram Schernthaner,
Maria Eugênia Fernandes Canziani,
Theodora TemelkovaKurktschiev,
Sheldon W. Tobe,
Fernando González,
Zhihong Liu,
Andrés Ángelo,
Cadena Bonfanti,
Carlos Jaramillo,
Martin Prázný,
Jorma Strand,
Michel Marre,
Roland E. Schmieder,
Christoph Wanner,
Pantelis Sarafidis,
Juliana C.N. Chan,
László Rosivall,
Joseph A. Eustace,
Ehud Grossman,
Yoram Yagil,
Giuseppe Remuzzi,
Daisuke Koya,
Takashi Wada,
Magdalena Madero Rovalo,
Ron T. Gansevoort,
Adriaan Kooy,
Trine Finnes,
Froilan De Leon,
Janusz Gumprecht,
Fernando Teixeira e Costa,
Alexander Dreval,
Anantharaman Vathsala,
Aslam Amod,
Sin Gon Kim,
ByungWan Lee,
Julio Pascual Santos,
Bengt-Olov Tengmark,
Michel Burnier,
ChienTe Lee,
Sukit Yamwong,
Ramazan Sarı,
Kieran McCafferty,
Borys Mankovsky,
Sharon G. Adler,
Linda P. Fried,
Robert Toto,
Mark V. Williams,
Tran Quang Khanh,
Diego Aizenberg,
Inés Bartolacci,
Diego Besada,
Julio Bittar,
Mariano Chahin,
Alicia Elbert,
Elizabeth Gelersztein,
Alberto Liberman,
Laura Maffei,
Federico Pérez Manghi,
Hugo Sanabria,
Gloria Viñes,
Alfredo Wassermann,
Walter P. Abhayaratna,
Shamasunder Acharya,
Elif I. Ekinci,
Darren Lee,
Peak Mann Mah,
Craig Nelson,
David Packham,
Alexia Pape,
Simon D. Roger,
Hugo Stephenson,
Michael Suranyi,
Gary Wittert,
Elizabeth Vale,
Martin Clodi,
Christoph Ebenbichler,
Evelyn Fließer-Görzer,
Ursula Hanusch,
Michael Krebs,
Karl Lhotta,
Bernhard Ludvik,
Gert Mayer,
Peter Neudorfer,
Bernhard Paulweber,
Rudolf Prager,
Wolfgang Preiß,
Friedrich C. Prischl,
G. Schernthaner,
Harald Sourij,
Martin Wiesholzer,
Peter Doubel,
W. Engelen,
JeanMichel Hougardy,
Jean-Marie Krzesinski,
Bart Maes,
Marijn M. Speeckaert,
Koen Stas,
Luc Van Gaal,
Hilde Vanbelleghem,
Daniela Antunes,
Roberto Botelho,
Cláudia Brito,
Luís Henrique Santos Canani,
Maria Cerqueira,
Rogério de Paula,
Freddy G. Eliaschewitz,
Carlos Eduardo PolideFigueiredo,
Adriana Costa e Forti,
Miguel Nasser Hissa,
Maurilo Leite,
Emerson de Lima,
Irene L. Noronha,
Bruno Paolino,
Nathalia Paschoalin,
Raphael Paschoalin,
Roberto Pecoits–Filho,
Marcio Pereira,
Evandro Portes,
Dalton Bertolim Précoma,
Rosângela Réa,
Miguel C. Riella,
João Eduardo Nunes Salles,
Eduardo Vasconcellos,
Sérgio Vencio,
Emiliya Apostolova,
Radostina Boshnyashka,
Ghassan Farah,
Dimitar Georgiev,
Valentina Gushterova,
Neli Klyuchkova,
Mariya Lucheva,
Petya Manova,
Dotska Minkova,
Boyan chev,
Mariyana Pichmanova,
Zhulieta Prakova,
Rangel Rangelov,
Rosen Rashkov,
Pavel Stanchev,
Bilyana Stoyanovska-Elencheva,
Zhivko Tagarev,
Theodora Temelkova-Kurktschieva,
S Vasileva,
Mariana Yoncheva-Mihaylova,
Paul E. Barré,
Brian Carlson,
James Conway,
Serge Cournoyer,
R Dumas,
Sameh Fikry,
Richard Goluch,
Pavel Hamet,
Randolph Hart,
Sam Henein,
Joanne Liutkus,
François Madore,
Valdemar Martinho,
Giuseppe Mazza,
Philip A. McFarlane,
Dennis D. O’Keefe,
Sean Peterson,
Daniel M. Schwartz,
Daniel Shu,
Andrew Steele,
Guy Tellier,
Karthik Tennankore,
George Tsoukas,
Richard Tytus,
Louise Vitou,
Michael Walsh,
S. John Weisnagel,
Igor Wilderman,
JeanFrançois Yale,
Jorge Cobos,
Juan Godoy,
Sergio Lobos,
Juan Carlos Palma,
Juan Carlos Prieto,
Eliana Reyes,
Carmen Romero,
Víctor Saavedra,
Mario Vega,
Ruifang Bu,
Cai H,
Nan Chen,
Qinkai Chen,
Dejun Chen,
Jinluo Cheng,
Youping Dong,
Junwu Dong,
Tianjun Guan,
ChuanMing Hao,
Wen Huang,
Fangfang Jiang,
Minxiang Lei,
Ling Li,
Zhonghe Li,
Xuemei Li,
Jingmei Li,
Yan Li,
Xinling Liang,
Bo Liang,
Fang Liu,
Yinghong Liu,
Yuan-Tao Liu,
Gang Long,
Guoyuan Lu,
Weiping Lu,
Yibing Lu,
Ping Luo,
Jianhua Ma,
Zhaohui Mo,
Jianying Niu,
Ai Peng,
Jiansong Shen,
Feixia Shen,
Bingyin Shi,
Qing Su,
Zhuxing Sun,
Shuifu Tang,
Nanwei Tong,
Hao Wang,
Xinjun Wang,
Lihua Wang,
Guixia Wang,
Jianqin Wang,
Yangang Wang,
Li Wang,
Jiali Wei,
Tianfeng Wu,
Chao-Qing Wu,
Xing Changying,
Fei Xiong,
Xudong Xu,
Ning Xu,
Tiekun Yan,
JinKui Yang,
Aiping Yin,
Longyi Zeng,
Hao Zhang,
Yanlin Zhang,
Ying Zhang,
Wenjing Zhao,
Zhiquan Zhao,
Hongguang Zheng,
Ling Zhong,
Dalong Zhu,
Yongze Zhuang,
Clara Arango,
Sandra Barrera,
Nelly Beltrán López,
Diego Benitez,
Guillermo Blanco,
Andrés Cadena,
Julián Coronel,
Carlos Cure,
Carlos Durán,
Alexander Ariel Padrón González,
Gustavo Guzmán,
Eric Hernández,
Jaime Ibarra,
Nicolás Jaramillo,
William Kattah,
Dora I. Molina,
Gregorio Sánchez,
Mónica Terront,
Freddy Trujillo,
Miguel UrinaTriana,
Ruben Vargas,
Iván Villegas,
Hernán Yupanqui,
D Alferi,
Michal Brada,
Jiri Brezina,
Petr Bucek,
Tomáš Edelsberger,
Drahomira Gulakova,
J Zapletalová,
Olga Hola,
Lucie Hornova,
Jana Houdova,
Helena Hrmova,
David Karásek,
Sarka Kopecka,
Richard Kovar,
Eva Krčová,
Jiří Kuchař,
Vlasta Kutejova,
H Lubanda,
Ivo Matyasek,
Magdaléna Mokrejšová,
Libor Okenka,
Jiri Pumprla,
Pavel Tománek,
Jesper Nørgaard Bech,
Jens Faber,
Gunnar Gislason,
Jørgen Hangaard,
Grzegorz Jaroslaw Pacyk,
Claus Bogh Juhl,
Thure Krarup,
Morten Lindhardt,
Sten Madsbad,
Joan Nielsen,
Ulrik PedersenBjergaard,
P. L. Poulsen,
Ole Rasmussen,
Karoline Schousboe,
Mikko Honkasalo,
Kari Humaloja,
Kristiina Kananen,
Ilkka Kantola,
Arvo Koistinen,
Pirkko Korsoff,
Jorma Lahtela,
Sakari Nieminen,
Tuomo Nieminen,
Karita Sadeharju,
Sakari Sulosaari,
Bertrand Cariou,
François Chantrel,
Sylvaine Clavel,
Christian Combe,
JeanPierre Fauvel,
Karim Gallouj,
D. Gouet,
Bruno Guerci,
Dominique Guerrot,
Maryvonne Hourmant,
Alexandre Klein,
Christophe Mariat,
Rafik Mesbah,
Yannick Le Meur,
Arnaud Monier,
Olivier Moranne,
Pierre Sérusclat,
Benoı̂t Vendrely,
Bruno Vergès,
Philippe Zaoui,
Christoph Axthelm,
Andreas Bergmann,
Andreas L. Birkenfeld,
Hermann Braun,
Klaus Busch,
Christel Contzen,
Stefan Degenhardt,
Karl Derwahl,
Thomas Giebel,
Andreas Hagenow,
Hermann Haller,
Christoph Hasslacher,
Thomas Horacek,
Wolfgang Jungmair,
C Kloos,
Thorsten Koch,
Thilo Krüger,
Anja Mühlfeld,
Joachim Müller,
Andreas Pfützner,
Frank Pistrosch,
Ludger Rose,
Lars Christian Rump,
Volker Schettler,
Ingolf Schiefke,
Heike Schlichthaar,
Bernd Schröppel,
Thomas Schürholz,
Helena Sigal,
Lutz Stemler,
Georg Strack,
Heidrun Täschner,
Nicole Toursarkissian,
Diethelm Tschöpe,
Achim Ulmer,
Markus van der Giet,
Bernhard R. Winkelmann,
Ioannis Boletis,
Erifili Hatziagelaki,
Ioannis Ioannidis,
Theodora Kounadi,
Ioanna Makriniotou,
Dorothea Papadopoulou,
Αikaterini Papagianni,
Ploumis Passadakis,
Ioannis Stefanidis,
Tai Pang Ip,
Paul Lee,
On Yan Andrea Luk,
Angela YeeMoon Wang,
Ming Wai Yeung,
Dóra Bajcsi,
P. Dános,
Eleonóra Harcsa,
Szilvia Kazup,
Katalin Keltai,
Róbert Kirschner,
Julianna Kiss,
László Kovács,
Beata Lamboy,
Botond Literáti-Nagy,
Margit Miléder,
László Nagy,
Ebrahim Noori,
Gábor Nyirati,
Gizella Petró,
Karoly Schneider,
Albert Szöcs,
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Z Zilahi,
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Joe Eustace,
John Holian,
Donal Reddan,
Yvonne O’Meara,
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Gil Chernin,
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Shai Efrati,
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Mariela Glandt,
Majdi Halabi,
Khaled Khazim,
Idit F. Liberty,
Ofri Mosenzon,
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Robert Zukermann,
Aneliya Parvanova,
Angelo Avogaro,
Giovanni Giorgio Battaglia,
Maurizio Bevilacqua,
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Carlo Antonio Bossi,
Paolo Calabrò,
Franco Cavalot,
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Michele Emdin,
Enrico Fiaccadori,
Paolo Fiorina,
Carlo Giorda,
Maria Cristina Gregorini,
Gaetano La Manna,
Davide Maggi,
Roberta Manti,
Giancarla Meregalli,
Antonello Pani,
Norberto Perico,
PierMarco Piatti,
Antonio Rosario Pisani,
Antonio E. Pontiroli,
Paola Ponzani,
Gennaro Santorelli,
Domenico Santoro,
Renzo Scanziani,
Ugo Teatini,
Giancarlo Tonolo,
Roberto Trevisan,
Anna Maria Veronelli,
Giorgio Luciano Viviani,
Hideo Araki,
Osamu Ebisui,
Naruhiro Fujita,
Ryuichi Furuya,
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Masahiro Hatazaki,
Terumasa Hayashi,
Takayuki Higashi,
Yoshihide Hirohata,
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Gabriel Ramos López,
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Hans Olav Høivik,
Thomas Karlsson,
Peter Scott Munk,
Maria Radtke,
Knut Risberg,
Jan Rocke,
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AudEldrid Stenehjem,
Anne-Beathe Tafjord,
Glenda Pamugas,
Araceli Panelo,
Ronald Perez,
Maribel Tanque,
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Michael Villa,
Patrycja Butrymowicz,
Kazimierz Ciechanowski,
Grażyna Cieślik,
Edward Franek,
Michal Hoffmann,
Jolanta Krzykowska,
Ilona Kurnatowska,
Katarzyna Landa,
Adam Madrzejewski,
Katarzyna Madziarska,
Stanisław Mazur,
Piotr Napora,
Michał Nowicki,
Anna Ocicka-Kozakiewicz,
Barbara Rewerska,
Teresa Rusicka,
Jan Ruxer,
Ewa Skokowska,
Andrzej Stankiewicz,
Tomasz Stompór,
Agnieszka Tiuryn-Petrulewicz,
Katarzyna Wasilewska,
Bogna WieruszWysocka,
Renata Wnętrzak-Michalska,
Edgar Almeida,
Rosa Ballesteros,
Carlos Barreto,
Idalina Beirão,
Rita Birne,
César Esteves,
José Guia,
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Olinda Marques,
Pedro Melo,
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Cristina Roque,
Francisco Rosário,
Gil Silva,
Ana Silva,
Ana Vila Lobos,
Gregorio Cortes-Maisonet,
Amaury Roman-Miranda,
Adrian Albota,
Cornelia Bala,
Hortensia Barbonta,
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Liana Turcu,
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Adrian Vlad,
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Andrey Babkin,
О. Л. Барбараш,
Vitaliy Baranov,
Elena Chernyavskaya,
Arkadiy Demko,
Anton Edin,
Polina Ermakova,
В. В. Фадеев,
А. S. Galyavich,
Leyla Gaysina,
И. Г. Гордеев,
Irina Ipatko,
Marina Kalashnikova,
Yuriy Khalimov,
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Л. Т. Пименов,
Elena Rechkova,
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О. Д. Рымар,
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Olga Semenova,
Alexander Sherenkov,
Oleg Solovev,
Е. А. Smolyarchuk,
Л. Г. Стронгин,
Olga P. Ukhanova,
Н. В. Верлан,
Natalya Vorokhobina,
D. A. Yakhontov,
S. S. Yаkushin,
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О. В. Занозина,
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Larisa Zhukova,
Tatyana A. Zykova,
Chee Fang Sum,
Sufi Muhummad Suhail,
Ru San Tan,
Edmund Wong,
Jana Babikova,
Ingrid Bugáňová,
Andrej Džupina,
Zuzana Ochodnicka,
Dalibor Sosovec,
Denisa Spodniakova,
Fayzal Ahmed,
Sindeep Bhana,
Larry A. Distiller,
Dirkie Jansen van Rensburg,
Mukesh C. Joshi,
Shaifali Joshi,
Deepak Lakha,
Essack Mitha,
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Naresh Ranjith,
Brian Rayner,
Paul Rheeder,
Mohamed Sarvan,
Mary Seeber,
Heidi Siebert,
Mohammed Tayob,
Julien Trokis,
Dorothea Urbach,
Louis van Zyl,
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Moon Gi Choi,
Choon Hee Chung,
YouCheol Hwang,
Chong Hwa Kim,
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Jae-Hyeon Kim,
SinGon Kim,
SungGyun Kim,
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Kang Wook Lee,
KookHwan Oh,
Ji Eun Oh,
Yun Kyu Oh,
DongJin Oh,
Junbeom Park,
Seok Joon Shin,
Su Ah Sung,
Jae Myung Yu,
Irene Agraz,
Francisco Javier Ampudia,
Hanane Bouarich,
Francesca Calero,
Cristina Castro,
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Josep Cruzado Garrit,
Fernando de Álvaro,
Josep Galcerán,
Olga González Albarrán,
Julio Hernández Jaras,
Meritxell Ibernón,
Francisco Martínez Deben,
Ma Dolores Martínez Esteban,
José María Pascual Izuel,
Judith Martins,
Juan Diego Mediavilla,
Alfredo MichánDoña,
Esteban Poch,
Manuel Polaina Rusillo,
Carlos Sánchez Juan,
Rafael Santamaría,
José Julián,
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Alfonso Soto,
Maribel Troya,
Annette Bruchfeld,
Dan Curiac,
Ken Eliasson,
Malin Frank,
Gregor Guron,
Olof Hellberg,
Margareta Hellgren,
Hans Larnefeldt,
Carl-Johan Lindholm,
Magnus Löndahl,
Erik ReinHedin,
Inga Soveri,
Jonas Spaak,
Daniel Ackermann,
Stefan Bilz,
Christian Förster,
Stefan Kalbermatter,
Andreas D. Kistler,
Antoinette Péchère-Bertschi,
Bernd Schultes,
ChizTzung Chang,
Cheng-Chieh Hung,
JuYing Jiang,
ShueiLiong Lin,
DerCherng Tarng,
ShihTe Tu,
KwanDun Wu,
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Chaicharn Deerochanawong,
Chagriya Kitiyakara,
Vuddhidej Ophascharoensuk,
Chatlert Pongchaiyakul,
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Necmi Eren,
İbrahim Gül,
Okan Gülel,
İsmail Koçyiğit,
Abdülbaki Kumbasar,
İdris Şahi̇n,
Burak Sayın,
Talat Tavlı,
Sedat Üstündağ,
Yavuz Yeniçerioğlu,
Iryna Bondarets,
Volodymyr Botsyurko,
Viktoriia Chernikova,
Oleksandra Donets,
I. M. Fushtey,
Mariia Grachova,
Anna Isayeva,
Dmytro Kogut,
Julia Komisarenko,
Н. А. Кравчун,
Kateryna Malyar,
Liliya Martynyuk,
Vitaliy Maslyanko,
Halyna Myshanych,
Larysa Pererva,
Н. О. Перцева,
Oleksandr Serhiyenko,
Ivan Smirnov,
Л.К. Соколова,
Vasyl Stryzhak,
Maryna Vlasenko,
Ahmad Abou-Saleh,
Jonathan Barratt,
Cuong Dang,
Hassan Kahal,
Adam Kirk,
Anne Kilvert,
Sui Phi Kon,
Dipesh Patel,
Sam Rice,
Vijayaraman Arutchelvam,
Yuk-ki Wong,
Martin Gibson,
Mona Wahba,
Reza Zaidi,
Idalia Acosta,
Atoya Adams,
Dilawar Ajani,
Slamat Ali,
Radica Z. Alicic,
Amer AlKaradsheh,
Sreedhara Alla,
Dale C. Allison,
Nabil Andrawis,
Ahmed Arif,
Ahmed K. Awad,
Masoud Azizad,
Michael Bahrami,
Shweta Bansal,
Steven Barag,
Ahmad Barakzoy,
Mark Barney,
Joshua I. Barzilay,
Khalid Bashir,
Jose Bautista,
Srinivasan Beddhu,
Diogo Belo,
Sabrina Benjamin,
Ramin Berenji,
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Jose Birriel,
Stephen Brietzke,
Frank C. Brosius,
Osvaldo Brusco,
Anna Burgner,
Robert S. Busch,
Rafael Canadas,
Maria Luiza Caramori,
José Cardona,
Christopher Case,
Humberto Cruz,
Ramprasad Dandillaya,
Dalia Dawoud,
Zia Ud Din,
Bradley P. Dixon,
Ankur Doshi,
James Drakakis,
Mahfouz El Shahawy,
Ashraf ElMeanawy,
Mohammed El-Shahawy,
John Evans,
George Z. Fadda,
Umar Farooq,
Roland Fernando,
Raymond Fink,
Brian First,
David Fitzpatrick,
John M. Flack,
Patrick Fluck,
Leon Fogelfeld,
Vivian Fonseca,
Juan P. Frías,
Claude Galphin,
Luis Garcia-Mayol,
Gary W. Goldstein,
Edgar R. Gonzalez,
Francisco Gonzalez-Abreu,
Ashwini Gore,
David Grant,
Violet Habwe,
Maxine Hamilton,
Jamal Hammoud,
Stuart Handelsman,
Israel Hartman,
Glenn Heigerick,
Andrew Henry,
Germán T. Hernández,
Carlos Hernández-Cassis,
Carlos Herrera,
Joachim Hertel,
Wenyu Huang,
Rogelio Iglesias,
Ali Iranmanesh,
Timothy Jackson,
Mahendra Jain,
Kenneth Jamerson,
Karen S. Johnson,
Eric Judd,
Joshua S. Kaplan,
Zeid Kayali,
Bobby V. Khan,
Mohammad Iqbal Khan,
Sourabh Kharait,
M. Sue Kirkman,
Nelson Kopyt,
Wayne Kotzker,
Csaba P. Kövesdy,
Camil Kreit,
Arvind Krishna,
Saeed Kronfli,
Keung Lee,
Derek LeJeune,
Brenda Lemus,
Carlos Leon-Forero,
Douglas Linfert,
Henry Lora,
Alexander Lurie,
Geetha Maddukuri,
Alexander R. Magno,
Louis Maletz,
Sreedhar Mandayam,
Mariana Markell,
Ronald K. Mayfield,
Caroline Mbogua,
Dierdre McMullen,
Carl Meisner,
Stephen D. Minton,
Bharat Mocherla,
Rajesh Mohandas,
Manuel Montero,
Moustafa Sherief Moustafa,
Salil Nadkarni,
Samer Nakhle,
Jesús Navarro,
Nilda Neyra,
Romanita Nica,
Philip Nicol,
Paul Norwood,
Visal Numrungroad,
Richard O’Donovan,
A. Ola Odugbesan,
Jorge Paoli-Bruno,
Samir V. Parikh,
Rakesh Patel,
Aldo J. Peixoto,
Pablo E. Pérgola,
Alan Perlman,
Karlton Pettis,
Roberto Pisoni,
Mirela Ponduchi,
Jorge Posada,
Sharma Prabhakar,
Jai Radhakrishnan,
Mahboob U. Rahman,
Rupesh Raina,
Anjay Rastogi,
Efrain Reisin,
Marc Rendell,
David Robertson,
Michael V. Rocco,
Hugo Romeu,
Sylvia E. Rosas,
Jack Rosenfeld,
Dennis L. Ross,
Jeffrey Rothman,
Lance Rudolph,
Yusuf Ruhullah,
Gary Ruoff,
Jeffrey Ryu,
Mandeep Sahani,
Ramin Sam,
Garfield Samuels,
William Sanchez,
Vladimir Santos,
Scott G. Satko,
Sanjeev Saxena,
David A. Scott,
Gilberto Seco,
Melvin Seek,
Harvey Serota,
Tariq Shafi,
Nauman Shahid,
Michael Shanik,
Santosh Sharma,
Arjun Sinha,
James Smelser,
Mark Smith,
Kyaw Soe,
Richard Solomon,
Eugene Soroka,
Joseph Soufer,
Bruce Spinowitz,
Leslie Spry,
Rosa Suarez,
Bala Subramanian,
Harold M. Szerlip,
Aparna Tamirisa,
Stephen Thomson,
Tuan-Huy Tran,
Richard Treger,
Gretel Trullenque,
Thomas Türk,
Guillermo E. Umpierrez,
Daniel Urbach,
Martin Valdes,
Shujauddin Valika,
Damaris Vega,
Peter N. Weissman,
Adam WhaleyConnell,
Jonathan Winston,
Jonathan Wise,
Alan Wynne,
Steven Zeig,
Phuong Chu,
Lam Van Hoang,
Nguyen Thi Phi Nga,
Pham Nguyen Son,
Lan Phuong Tran
Publication year - 2022
Publication title -
diabetes care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.636
H-Index - 363
eISSN - 1935-5548
pISSN - 0149-5992
DOI - 10.2337/dc21-1944
Subject(s) - medicine , diabetes mellitus , type 2 diabetes , kidney disease , insulin , disease , baseline (sea) , endocrinology , oceanography , geology
OBJECTIVE Finerenone significantly improved cardiorenal outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) in the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease trial. We explored whether baseline HbA1c level and insulin treatment influenced outcomes. RESEARCH DESIGN AND METHODS Patients with T2D, urine albumin-to-creatinine ratio (UACR) of 30–5,000 mg/g, estimated glomerular filtration rate (eGFR) of 25 to <75 mL/min/1.73 m2, and treated with optimized renin–angiotensin system blockade were randomly assigned to receive finerenone or placebo. Efficacy outcomes included kidney (kidney failure, sustained decrease ≥40% in eGFR from baseline, or renal death) and cardiovascular (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) composite endpoints. Patients were analyzed by baseline insulin use and by baseline HbA1c <7.5% (58 mmol/mol) or ≥7.5%. RESULTS Of 5,674 patients, 3,637 (64.1%) received insulin at baseline. Overall, 5,663 patients were included in the analysis for HbA1c; 2,794 (49.3%) had baseline HbA1c <7.5% (58 mmol/mol). Finerenone significantly reduced risk of the kidney composite outcome independent of baseline HbA1c level and insulin use (Pinteraction = 0.41 and 0.56, respectively). Cardiovascular composite outcome incidence was reduced with finerenone irrespective of baseline HbA1c level and insulin use (Pinteraction = 0.70 and 0.33, respectively). Although baseline HbA1c level did not affect kidney event risk, cardiovascular risk increased with higher HbA1c level. UACR reduction was consistent across subgroups. Adverse events were similar between groups regardless of baseline HbA1c level and insulin use; few finerenone-treated patients discontinued treatment because of hyperkalemia. CONCLUSIONS Finerenone reduces kidney and cardiovascular outcome risk in patients with CKD and T2D, and risks appear consistent irrespective of HbA1c levels or insulin use.
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