Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes | Zendy

Kamel Mohammedi | Zendy; Yawa Abouleka | Zendy; Charlyne Carpentier | Zendy; Louis Potier | Zendy; Séverine Dubois | Zendy; Ni Foussard | Zendy; Vincent Rigalleau | Zendy; JeanFrançois Gautier | Zendy; Pierre Gourdy | Zendy; G. Charpentier | Zendy; Ronan Roussel | Zendy; André Scheen | Zendy; B. Bauduceau | Zendy; Samy Hadjadj | Zendy; François Alhenc–Gelas | Zendy; Michel Marre | Zendy; Gilberto Velho | Zendy

Open Access

Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes

Author(s) -

Kamel Mohammedi,

Yawa Abouleka,

Charlyne Carpentier,

Louis Potier,

Séverine Dubois,

Ni Foussard,

Vincent Rigalleau,

JeanFrançois Gautier,

Pierre Gourdy,

G. Charpentier,

Ronan Roussel,

André Scheen,

B. Bauduceau,

Samy Hadjadj,

François Alhenc–Gelas,

Michel Marre,

Gilberto Velho

Publication year - 2021

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc21-0973

Subject(s) - medicine , amputation , hazard ratio , diabetes mellitus , odds ratio , type 2 diabetes , genotype , confounding , proportional hazards model , diabetic foot , prospective cohort study , surgery , confidence interval , gastroenterology , endocrinology , genetics , biology , gene

The ACE insertion/deletion (I/D) polymorphism has been widely studied in people with diabetes, albeit not with regard to lower-limb amputation (LLA). We examined associations among this polymorphism, plasma ACE concentration, and LLA in people with type 1 diabetes.

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