Polycystic Ovary Syndrome, Combined Oral Contraceptives, and the Risk of Dysglycemia: A Population-Based Cohort Study With a Nested Pharmacoepidemiological Case-Control Study | Zendy

Balachandran Kumarendran | Zendy; Michael OʼReilly | Zendy; Anuradhaa Subramanian | Zendy; Dana Šumilo | Zendy; Konstantinos A. Toulis | Zendy; Krishna Gokhale | Zendy; Chandrika Neelakanthi Wijeratne | Zendy; Arri Coomarasamy | Zendy; Abd A. Tahrani | Zendy; Laurent Azoulay | Zendy; Wiebke Arlt | Zendy; Krishnarajah Nirantharakumar | Zendy

Open Access

Polycystic Ovary Syndrome, Combined Oral Contraceptives, and the Risk of Dysglycemia: A Population-Based Cohort Study With a Nested Pharmacoepidemiological Case-Control Study

Author(s) -

Balachandran Kumarendran,

Michael OʼReilly,

Anuradhaa Subramanian,

Dana Šumilo,

Konstantinos A. Toulis,

Krishna Gokhale,

Chandrika Neelakanthi Wijeratne,

Arri Coomarasamy,

Abd A. Tahrani,

Laurent Azoulay,

Wiebke Arlt,

Krishnarajah Nirantharakumar

Publication year - 2021

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc21-0437

Subject(s) - medicine , polycystic ovary , hazard ratio , population , nested case control study , odds ratio , obstetrics , retrospective cohort study , type 2 diabetes , cohort study , gynecology , diabetes mellitus , endocrinology , confidence interval , insulin resistance , environmental health

Irregular menstrual cycles are associated with increased cardiovascular mortality. Polycystic ovary syndrome (PCOS) is characterized by androgen excess and irregular menses; androgens are drivers of increased metabolic risk in women with PCOS. Combined oral contraceptive pills (COCPs) are used in PCOS both for cycle regulation and to reduce the biologically active androgen fraction. We examined COCP use and risk of dysglycemia (prediabetes and type 2 diabetes) in women with PCOS.

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