Is the Consensual Threshold for Defining High Glucose Variability Implementable in Clinical Practice? | Zendy

JeanBaptiste Julla | Zendy; Pauline Jacquemier | Zendy; Guy Fagherazzi | Zendy; Tiphaine Vidal-Trécan | Zendy; Vanessa Juddoo | Zendy; Asma Jaziri | Zendy; Hanane Mersel | Zendy; Nicolas Venteclef | Zendy; Ronan Roussel | Zendy; Pascale Massin | Zendy; Aude Couturier | Zendy; JeanFrançois Gautier | Zendy; JeanPierre Riveline | Zendy

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Is the Consensual Threshold for Defining High Glucose Variability Implementable in Clinical Practice?

Author(s) -

JeanBaptiste Julla,

Pauline Jacquemier,

Guy Fagherazzi,

Tiphaine Vidal-Trécan,

Vanessa Juddoo,

Asma Jaziri,

Hanane Mersel,

Nicolas Venteclef,

Ronan Roussel,

Pascale Massin,

Aude Couturier,

JeanFrançois Gautier,

JeanPierre Riveline

Publication year - 2021

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc20-1847

Subject(s) - medicine , coefficient of variation , glycemic , population , diabetes mellitus , continuous glucose monitoring , endocrinology , statistics , mathematics , environmental health

OBJECTIVE Estimating glycemic variability (GV) through within-day coefficient of variation (%CVw) is recommended for patients with type 1 Diabetes (T1D). High GV (hGV) is defined as %CVw > 36%. However, continuous glucose monitoring (CGM) devices provide exclusively total CV (%CVT). We aimed to assess consequences of this disparity. RESEARCH DESIGN AND METHODS We retrospectively calculated both %CVT and %CVw of consecutive T1D patients from their CGM raw data during 14 days. Patients with hGV with %CVT >36% and %CVw ≤36% were called the “inconsistent GV group”. RESULTS A total of 104 patients were included. Mean ± SD %CVT and %CVw were 42.4 ± 8% and 37.0 ± 7.4% respectively (P < 0.0001). Using %CVT, 81 patients (73.6%) were classified as having hGV, whereas 59 (53.6%) using %CVw (P < 0.0001) corresponding to 22 patients (21%) in the inconsistent GV population. CONCLUSIONS Evaluation of GV through %CV in patients with T1D is highly dependent on the calculation method and then must be standardized.

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