Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes | Zendy

Jasna Šuput Omladič | Zendy; Anka Slana Ozimič | Zendy; Andrej Vovk | Zendy; Dušan Šuput | Zendy; Grega Repovš | Zendy; Klemen Dovč | Zendy; Nataša Bratina | Zendy; Magdalena Avbelj Stefanija | Zendy; Tadej Battelino | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes

Author(s) -

Jasna Šuput Omladič,

Anka Slana Ozimič,

Andrej Vovk,

Dušan Šuput,

Grega Repovš,

Klemen Dovč,

Nataša Bratina,

Magdalena Avbelj Stefanija,

Tadej Battelino

Publication year - 2020

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc20-0171

Subject(s) - medicine , type 1 diabetes , diabetes mellitus , working memory , session (web analytics) , type 2 diabetes , pediatrics , endocrinology , cognition , psychiatry , world wide web , computer science

OBJECTIVE To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). RESULTS Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed. CONCLUSIONS Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research