A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study | Zendy

Robert G. Frykberg | Zendy; Peter Franks | Zendy; Michael Edmonds | Zendy; Jonathan N. Brantley | Zendy; Luc Téot | Zendy; Thomas Wild | Zendy; Matthew G. Garoufalis | Zendy; Aliza M. Lee | Zendy; Janette A. Thompson | Zendy; Gérard Reach | Zendy; Cyaandi Dove | Zendy; Karim Lachgar | Zendy; D. Grotemeyer | Zendy; Sophie Renton | Zendy

Open Access

A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study

Author(s) -

Robert G. Frykberg,

Peter Franks,

Michael Edmonds,

Jonathan N. Brantley,

Luc Téot,

Thomas Wild,

Matthew G. Garoufalis,

Aliza M. Lee,

Janette A. Thompson,

Gérard Reach,

Cyaandi Dove,

Karim Lachgar,

D. Grotemeyer,

Sophie Renton

Publication year - 2020

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc19-0476

Subject(s) - medicine , diabetic foot , placebo , diabetes mellitus , hazard ratio , randomized controlled trial , surgery , clinical endpoint , odds ratio , confidence interval , alternative medicine , pathology , endocrinology

Topical oxygen has been used for the treatment of chronic wounds for more than 50 years. Its effectiveness remains disputed due to the limited number of robust high-quality investigations. The aim of this study was to assess the efficacy of multimodality cyclical pressure Topical Wound Oxygen (TWO2) home care therapy in healing refractory diabetic foot ulcers (DFUs) that had failed to heal with standard of care (SOC) alone.

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