Association of Serum Retinol-Binding Protein 4 Levels and the Risk of Incident Type 2 Diabetes in Subjects With Prediabetes | Zendy

Jiahua Fan | Zendy; Songping Yin | Zendy; Diaozhu Lin | Zendy; Yangqing Liu | Zendy; Nixuan Chen | Zendy; Xinxiu Bai | Zendy; Qiuyi Ke | Zendy; Jia Shen | Zendy; Lili You | Zendy; Xiuhong Lin | Zendy; Feng Li | Zendy; Fengyi He | Zendy; Li Yan | Zendy; Chaogang Chen | Zendy; Min Xia | Zendy

Open Access

Association of Serum Retinol-Binding Protein 4 Levels and the Risk of Incident Type 2 Diabetes in Subjects With Prediabetes

Author(s) -

Jiahua Fan,

Songping Yin,

Diaozhu Lin,

Yangqing Liu,

Nixuan Chen,

Xinxiu Bai,

Qiuyi Ke,

Jia Shen,

Lili You,

Xiuhong Lin,

Feng Li,

Fengyi He,

Li Yan,

Chaogang Chen,

Min Xia

Publication year - 2019

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc19-0265

Subject(s) - prediabetes , medicine , retinol binding protein 4 , type 2 diabetes , diabetes mellitus , glycated hemoglobin , impaired fasting glucose , insulin resistance , population , endocrinology , hazard ratio , prospective cohort study , risk factor , impaired glucose tolerance , confidence interval , adipokine , environmental health

OBJECTIVE To explore the association of serum retinol-binding protein 4 (RBP4) levels and risk for the development of type 2 diabetes in individuals with prediabetes. RESEARCH DESIGN AND METHODS A population-based prospective study was conducted among 1,011 Chinese participants with prediabetes (average age 55.6 ± 7.2 years). Incident type 2 diabetes was diagnosed according to the American Diabetes Association 2010 criteria. Serum RBP4 levels were measured using a commercially available ELISA. We analyzed the association of serum RBP4 levels with the risk of incident type 2 diabetes using the Cox proportional hazards model. RESULTS During a median follow-up period of 3.1 years, 153 participants developed incident type 2 diabetes. A U-shaped association was observed between serum RBP4 levels and the risk of incident type 2 diabetes, with the lowest risk in the RBP4 range of 31–55 μg/mL. Multivariate Cox regression model analysis showed that serum RBP4 levels <31 μg/mL and RBP4 levels >55 μg/mL were associated with an increased risk of incident type 2 diabetes. The adjusted hazard ratios (95% CI) were 2.01 (1.31–3.09) and 1.97 (1.32–2.93), respectively, after adjusting for age, sex, BMI, waist circumference, γ-glutamyltransferase, HOMA of insulin resistance index, fasting plasma glucose, 2-h plasma glucose, and glycated hemoglobin (HbA1c) levels. CONCLUSIONS A U-shaped relationship exists between serum RBP4 levels and the risk of incident type 2 diabetes in subjects with prediabetes.

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