Children Exposed to Maternal Obesity or Gestational Diabetes Mellitus During Early Fetal Development Have Hypothalamic Alterations That Predict Future Weight Gain | Zendy

Kathleen A. Page | Zendy; Shan Luo | Zendy; Xinhui Wang | Zendy; Ting Chow | Zendy; Jasmin M. Alves | Zendy; Thomas A. Buchanan | Zendy; Anny H. Xiang | Zendy

Open Access

Children Exposed to Maternal Obesity or Gestational Diabetes Mellitus During Early Fetal Development Have Hypothalamic Alterations That Predict Future Weight Gain

Author(s) -

Kathleen A. Page,

Shan Luo,

Xinhui Wang,

Ting Chow,

Jasmin M. Alves,

Thomas A. Buchanan,

Anny H. Xiang

Publication year - 2019

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc18-2581

Subject(s) - medicine , offspring , gestational diabetes , in utero , pregnancy , endocrinology , obesity , diabetes mellitus , body mass index , gestation , anthropometry , childhood obesity , birth weight , fetus , physiology , obstetrics , overweight , biology , genetics

Exposure in utero to maternal obesity or gestational diabetes mellitus (GDM) is linked to a high risk for obesity in offspring. Animal studies suggest that these exposures disrupt the development of the hypothalamus, a brain region that regulates body weight, predisposing offspring to develop obesity. This study tested the hypothesis in humans that in utero exposure to maternal obesity and/or GDM is associated with alterations in the hypothalamic response to glucose and the altered hypothalamic response would predict greater increases in child adiposity 1 year later.

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