Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study | Zendy

Joanna Kłubo-Gwieździńska | Zendy; Maria Lange | Zendy; Elaine Cochran | Zendy; Robert K. Semple | Zendy; Cornelia Gewert | Zendy; Rebecca J. Brown | Zendy; Phillip Görden | Zendy

Open Access

Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study

Author(s) -

Joanna Kłubo-Gwieździńska,

Maria Lange,

Elaine Cochran,

Robert K. Semple,

Cornelia Gewert,

Rebecca J. Brown,

Phillip Görden

Publication year - 2018

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc18-0884

Subject(s) - medicine , interquartile range , discontinuation , insulin , gastroenterology , prospective cohort study , type 2 diabetes , insulin resistance , azathioprine , diabetes mellitus , endocrinology , disease

Type B insulin resistance due to autoantibodies against the insulin receptor is characterized by diabetes refractory to massive doses of insulin, severe hypercatabolism, hyperandrogenism, and a high mortality rate. We analyzed the efficacy of combined immunosuppressive therapy in the management of this extreme form of diabetes.

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