Clusterin Impairs Hepatic Insulin Sensitivity and Adipocyte Clusterin Associates With Cardiometabolic Risk | Zendy

David Bradley | Zendy; Alecia Blaszczak | Zendy; Zheng Yin | Zendy; Joey Liu | Zendy; Joshua J. Joseph | Zendy; Valerie P. Wright | Zendy; Kajol Anandani | Zendy; Bradley Needleman | Zendy; Sabreoria | Zendy; David Renton | Zendy; Martha Yearsley | Zendy; Stephen T.C. Wong | Zendy; Willa A. Hsueh | Zendy

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Clusterin Impairs Hepatic Insulin Sensitivity and Adipocyte Clusterin Associates With Cardiometabolic Risk

Author(s) -

David Bradley,

Alecia Blaszczak,

Zheng Yin,

Joey Liu,

Joshua J. Joseph,

Valerie P. Wright,

Kajol Anandani,

Bradley Needleman,

Sabreoria,

David Renton,

Martha Yearsley,

Stephen T.C. Wong,

Willa A. Hsueh

Publication year - 2019

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc18-0870

Subject(s) - clusterin , adipocyte , endocrinology , medicine , insulin resistance , adipose tissue , fatty liver , diabetes mellitus , disease , biology , apoptosis , biochemistry

Components of the adipose tissue (AT) extracellular matrix (ECM) are recently discovered contributors to obesity-related cardiometabolic disease. We identified increased adipocyte expression of ECM-related clusterin (apolipoprotein J) in obese versus lean women by microarray. Our objective was to determine 1 ) whether subcutaneous AT adipocyte (SAd) clusterin and serum clusterin are associated with insulin resistance (IR) and known markers of cardiometabolic risk and 2 ) how clusterin may contribute to increased risk.

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