Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars | Zendy

Panu K. Luukkonen | Zendy; Sanja Sädevirta | Zendy; You Zhou | Zendy; Brandon D. Kayser | Zendy; Ashfaq Ali | Zendy; Linda Ahonen | Zendy; Susanna Lallukka | Zendy; Véronique Pelloux | Zendy; Melania Gaggini | Zendy; Ching Jian | Zendy; Antti Hakkarainen | Zendy; Nina Lundbom | Zendy; Helena Gylling | Zendy; Anne Salonen | Zendy; Matej Orešič | Zendy; Tuulia Hyötyläinen | Zendy; Marju OrhoMelander | Zendy; Aila Rissanen | Zendy; Amalia Gastaldelli | Zendy; Karine Clément | Zendy; Leanne Hodson | Zendy; Hannele YkiJärvinen | Zendy

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Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

Author(s) -

Panu K. Luukkonen,

Sanja Sädevirta,

You Zhou,

Brandon D. Kayser,

Ashfaq Ali,

Linda Ahonen,

Susanna Lallukka,

Véronique Pelloux,

Melania Gaggini,

Ching Jian,

Antti Hakkarainen,

Nina Lundbom,

Helena Gylling,

Anne Salonen,

Matej Orešič,

Tuulia Hyötyläinen,

Marju OrhoMelander,

Aila Rissanen,

Amalia Gastaldelli,

Karine Clément,

Leanne Hodson,

Hannele YkiJärvinen

Publication year - 2018

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc18-0071

Subject(s) - lipolysis , medicine , endocrinology , lipogenesis , adipose tissue , triglyceride , insulin resistance , diabetes mellitus , obesity , fatty liver , cholesterol , disease

Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrient composition influences the pathways, mediators, and magnitude of weight gain-induced changes in IHTG.

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