Improved Health-Related Quality of Life in a Phase 3 Islet Transplantation Trial in Type 1 Diabetes Complicated by Severe Hypoglycemia | Zendy

Eric D. Foster | Zendy; Nancy D. Bridges | Zendy; Irene D. Feurer | Zendy; Thomas L. Eggerman | Zendy; Lawrence G. Hunsicker | Zendy; Rodolfo Alejandro | Zendy; Beth Begley | Zendy; Jose Cano | Zendy; Sallie Carpentier | Zendy; Jennifer Hutchinson | Zendy; Christian P. Larsen | Zendy; Johanna Moreno | Zendy; Marti H. Sears | Zendy; Nicole A. Turgeon | Zendy; Dasia Webster | Zendy; James F. Markmann | Zendy; Patrice AlSaden | Zendy; Xioajuan Chen | Zendy; Angela Hecyk | Zendy; Xunrong Luo | Zendy; Mark E. Molitch | Zendy; Natalie Monson | Zendy; Elyse Stuart | Zendy; Amisha Wallia | Zendy; LingJia Wang | Zendy; Shusen Wang | Zendy; Xiaomin Zhang | Zendy; Christine W. Czarniecki | Zendy; Julia Goldstein | Zendy; Allison Priore | Zendy; Mark A. Robien | Zendy; Elizabeth M. Schneider | Zendy; Guillermo Arreaza-Rubín | Zendy; Neal Green | Zendy; David L. Bigam | Zendy; Patricia Campbell | Zendy; Parastoo Dinyari | Zendy; Tatsuya Kin | Zendy; Norman M. Kneteman | Zendy; James Lyon | Zendy; Andrew J. Malcolm | Zendy; Doug O’Gorman | Zendy; Chris Onderka | Zendy; Richard Owen | Zendy; Rena Pawlick | Zendy; Brad Richer | Zendy; Shawn Rosichuk | Zendy; Donna Sarman | Zendy; Adam Schroeder | Zendy; Peter Senior | Zendy; A. M. James Shapiro | Zendy; Lana Toth | Zendy; Vali Toth | Zendy; Wendy Zhai | Zendy; Kristina Johnson | Zendy; Joan McElroy | Zendy; Andrew M. Posselt | Zendy; Marissa Ramos | Zendy; Tara Rojas | Zendy; Peter G. Stock | Zendy; Gregory L. Szot | Zendy; Barbara Barbaro | Zendy; Joan Martellotto | Zendy; José Oberholzer | Zendy; Meirigeng Qi | Zendy; Yong Wang | Zendy; Levent Bayman | Zendy; Kathryn Chaloner | Zendy; William R. Clarke | Zendy; Joseph S. Dillon | Zendy; Cynthia Diltz | Zendy; Gregory C. Doelle | Zendy; Dixie Ecklund | Zendy; Deb Feddersen | Zendy; Carol Jasperson | Zendy; David-Erick Lafontant | Zendy; Tieill-Hudson | Zendy; Deb Nollen | Zendy; Julie C. Qidwai | Zendy; Holly Riss | Zendy; Traci Schwieger | Zendy; Jamie Willits | Zendy; Jon Yankey | Zendy; Andrea Curry Corrales | Zendy; Raquel N. Faradji | Zendy; Tatiana Froud | Zendy; Ana Alvarez Gil | Zendy; Eva Herrada | Zendy; Luca Inverardi | Zendy; Norma S. Kenyon | Zendy; Aisha Khan | Zendy; Elina Linetsky | Zendy; Eduardo Peixoto | Zendy; Camillo Ricordi | Zendy; Muhamad H. Abdulla | Zendy; Appakalai N. Balamurugan | Zendy; Melena D. Bellin | Zendy; Mary Brandenburg | Zendy; James V. Harmon | Zendy; Bernhard J. Hering | Zendy; Raja Kandaswamy | Zendy; Gopal Loganathan | Zendy; Kate R. Mueller | Zendy; Klearchos K. Papas | Zendy; J Højgaard Pedersen | Zendy; Joshua J. Wilhelm | Zendy; Jean C. Witson | Zendy; Cornelia Dalton-Bakes | Zendy; Hongxing Fu | Zendy; Malek Kamoun | Zendy; Jane Kearns | Zendy; Yanjing Li | Zendy; Chengyang Liu | Zendy; Eline Luning-Prak | Zendy; Yanping Luo | Zendy; Eileen Markmann | Zendy; Zaw Min | Zendy; Ali Naji | Zendy; Maral Palanjian | Zendy; Michael R. Rickels | Zendy; Richard D. Shlansky-Goldberg | Zendy; Kumar Vivek | Zendy; Amin Sam Ziaie | Zendy; Dixon B. Kaufman | Zendy; Olle Korsgren | Zendy

Open Access

Improved Health-Related Quality of Life in a Phase 3 Islet Transplantation Trial in Type 1 Diabetes Complicated by Severe Hypoglycemia

Author(s) -

Eric D. Foster,

Nancy D. Bridges,

Irene D. Feurer,

Thomas L. Eggerman,

Lawrence G. Hunsicker,

Rodolfo Alejandro,

Beth Begley,

Jose Cano,

Sallie Carpentier,

Jennifer Hutchinson,

Christian P. Larsen,

Johanna Moreno,

Marti H. Sears,

Nicole A. Turgeon,

Dasia Webster,

James F. Markmann,

Patrice AlSaden,

Xioajuan Chen,

Angela Hecyk,

Xunrong Luo,

Mark E. Molitch,

Natalie Monson,

Elyse Stuart,

Amisha Wallia,

LingJia Wang,

Shusen Wang,

Xiaomin Zhang,

Christine W. Czarniecki,

Julia Goldstein,

Allison Priore,

Mark A. Robien,

Elizabeth M. Schneider,

Guillermo Arreaza-Rubín,

Neal Green,

David L. Bigam,

Patricia Campbell,

Parastoo Dinyari,

Tatsuya Kin,

Norman M. Kneteman,

James Lyon,

Andrew J. Malcolm,

Doug O’Gorman,

Chris Onderka,

Richard Owen,

Rena Pawlick,

Brad Richer,

Shawn Rosichuk,

Donna Sarman,

Adam Schroeder,

Peter Senior,

A. M. James Shapiro,

Lana Toth,

Vali Toth,

Wendy Zhai,

Kristina Johnson,

Joan McElroy,

Andrew M. Posselt,

Marissa Ramos,

Tara Rojas,

Peter G. Stock,

Gregory L. Szot,

Barbara Barbaro,

Joan Martellotto,

José Oberholzer,

Meirigeng Qi,

Yong Wang,

Levent Bayman,

Kathryn Chaloner,

William R. Clarke,

Joseph S. Dillon,

Cynthia Diltz,

Gregory C. Doelle,

Dixie Ecklund,

Deb Feddersen,

Carol Jasperson,

David-Erick Lafontant,

Tieill-Hudson,

Deb Nollen,

Julie C. Qidwai,

Holly Riss,

Traci Schwieger,

Jamie Willits,

Jon Yankey,

Andrea Curry Corrales,

Raquel N. Faradji,

Tatiana Froud,

Ana Alvarez Gil,

Eva Herrada,

Luca Inverardi,

Norma S. Kenyon,

Aisha Khan,

Elina Linetsky,

Eduardo Peixoto,

Camillo Ricordi,

Muhamad H. Abdulla,

Appakalai N. Balamurugan,

Melena D. Bellin,

Mary Brandenburg,

James V. Harmon,

Bernhard J. Hering,

Raja Kandaswamy,

Gopal Loganathan,

Kate R. Mueller,

Klearchos K. Papas,

J Højgaard Pedersen,

Joshua J. Wilhelm,

Jean C. Witson,

Cornelia Dalton-Bakes,

Hongxing Fu,

Malek Kamoun,

Jane Kearns,

Yanjing Li,

Chengyang Liu,

Eline Luning-Prak,

Yanping Luo,

Eileen Markmann,

Zaw Min,

Ali Naji,

Maral Palanjian,

Michael R. Rickels,

Richard D. Shlansky-Goldberg,

Kumar Vivek,

Amin Sam Ziaie,

Dixon B. Kaufman,

Olle Korsgren

Publication year - 2018

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc17-1779

Subject(s) - medicine , glycemic , hypoglycemia , transplantation , type 1 diabetes , quality of life (healthcare) , diabetes mellitus , islet , randomized controlled trial , distress , endocrinology , clinical psychology , nursing

Attaining glycemic targets without severe hypoglycemic events (SHEs) is a challenging treatment goal for patients with type 1 diabetes complicated by impaired awareness of hypoglycemia (IAH). The CIT Consortium Protocol 07 (CIT-07) trial showed islet transplantation to be an effective treatment for subjects with IAH and intractable SHEs. We evaluated health-related quality of life (HRQOL), functional health status, and health utility before and after pancreatic islet transplantation in CIT-07 trial participants.

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