Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation | Zendy

Qin Wang | Zendy; Michael V. Holmes | Zendy; George Davey Smith | Zendy; Mika AlaKorpela | Zendy

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Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation

Author(s) -

Qin Wang,

Michael V. Holmes,

George Davey Smith,

Mika AlaKorpela

Publication year - 2017

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc17-1642

Subject(s) - mendelian randomization , insulin resistance , pleiotropy , medicine , valine , genome wide association study , endocrinology , insulin , single nucleotide polymorphism , diabetes mellitus , type 2 diabetes , genetics , genotype , biology , amino acid , genetic variants , gene , phenotype

Insulin resistance has deleterious effects on cardiometabolic disease. We used Mendelian randomization analyses to clarify the causal relationships of insulin resistance (IR) on circulating blood-based metabolites to shed light on potential mediators of the IR to cardiometabolic disease relationship.

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