Application of Zone Model Predictive Control Artificial Pancreas During Extended Use of Infusion Set and Sensor: A Randomized Crossover-Controlled Home-Use Trial | Zendy

Gregory P. Forlenza | Zendy; Sunil Deshpande | Zendy; Trang T. Ly | Zendy; Daniel P. Howsmon | Zendy; Faye Cameron | Zendy; Nihat Baysal | Zendy; Eric Mauritzen | Zendy; Tatiana Marcal | Zendy; Lindsey Towers | Zendy; B. Wayne Bequette | Zendy; Lauren M. Huyett | Zendy; Jordan E. Pinsker | Zendy; Ravi Gondhalekar | Zendy; Francis J. Doyle | Zendy; David M. Maahs | Zendy; Bruce A. Buckingham | Zendy; Eyal Dassau | Zendy

Open Access

Application of Zone Model Predictive Control Artificial Pancreas During Extended Use of Infusion Set and Sensor: A Randomized Crossover-Controlled Home-Use Trial

Author(s) -

Gregory P. Forlenza,

Sunil Deshpande,

Trang T. Ly,

Daniel P. Howsmon,

Faye Cameron,

Nihat Baysal,

Eric Mauritzen,

Tatiana Marcal,

Lindsey Towers,

B. Wayne Bequette,

Lauren M. Huyett,

Jordan E. Pinsker,

Ravi Gondhalekar,

Francis J. Doyle,

David M. Maahs,

Bruce A. Buckingham,

Eyal Dassau

Publication year - 2017

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc17-0500

Subject(s) - medicine , crossover study , artificial pancreas , glycemic , randomized controlled trial , diabetes mellitus , continuous glucose monitoring , insulin , blood glucose self monitoring , surgery , gastroenterology , endocrinology , type 1 diabetes , alternative medicine , pathology , placebo

As artificial pancreas (AP) becomes standard of care, consideration of extended use of insulin infusion sets (IIS) and continuous glucose monitors (CGMs) becomes vital. We conducted an outpatient randomized crossover study to test the safety and efficacy of a zone model predictive control (zone-MPC)-based AP system versus sensor augmented pump (SAP) therapy in which IIS and CGM failures were provoked via extended wear to 7 and 21 days, respectively.

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