Renal Handling of Ketones in Response to Sodium–Glucose Cotransporter 2 Inhibition in Patients With Type 2 Diabetes | Zendy

Ele Ferrannini | Zendy; Simona Baldi | Zendy; Silvia Frascerra | Zendy; Brenno Astiarraga | Zendy; E. Barsotti | Zendy; Aldo Clerico | Zendy; Elza Muscelli | Zendy

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Renal Handling of Ketones in Response to Sodium–Glucose Cotransporter 2 Inhibition in Patients With Type 2 Diabetes

Author(s) -

Ele Ferrannini,

Simona Baldi,

Silvia Frascerra,

Brenno Astiarraga,

E. Barsotti,

Aldo Clerico,

Elza Muscelli

Publication year - 2017

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc16-2724

Subject(s) - medicine , endocrinology , glycosuria , renal function , type 2 diabetes , diabetes mellitus , renal glucose reabsorption , excretion , empagliflozin

Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis and hormone release, including decrements in plasma glucose and insulin levels, increments in glucagon release, enhanced lipolysis, and stimulation of ketogenesis, resulting in an increase in ketonemia. We aimed at assessing the renal response to these changes.

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