Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial | Zendy

John M. Lachin | Zendy; Ionut Bebu | Zendy; Richard M. Bergenstal | Zendy; Rodica PopBusui | Zendy; F. John Service | Zendy; Bernard Zinman | Zendy; David M. Nathan | Zendy

Open Access

Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial

Author(s) -

John M. Lachin,

Ionut Bebu,

Richard M. Bergenstal,

Rodica PopBusui,

F. John Service,

Bernard Zinman,

David M. Nathan

Publication year - 2017

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc16-2426

Subject(s) - medicine , glycemic , diabetes mellitus , microalbuminuria , nephropathy , retinopathy , type 1 diabetes , diabetic retinopathy , endocrinology

The Diabetes Control and Complications Trial (DCCT) demonstrated the beneficial effects of intensive versus conventional therapy on the development and progression of microvascular complications of type 1 diabetes. These beneficial effects were almost completely explained by the difference between groups in the levels of HbA 1c , which in turn were associated with the risk of these complications. We assessed the association of glucose variability within and between quarterly 7-point glucose profiles with the development and progression of retinopathy, nephropathy, and cardiovascular autonomic neuropathy during the DCCT.

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