Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development? | Zendy

Christine T. Ferrara | Zendy; Susan Geyer | Zendy; YF Liu | Zendy; Carmella EvansMolina | Zendy; Ingrid Libman | Zendy; Rachel Besser | Zendy; Dorothy Becker | Zendy; Henry Rodriguez | Zendy; Antoinette Moran | Zendy; Stephen E. Gitelman | Zendy; María J. Redondo | Zendy

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Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?

Author(s) -

Christine T. Ferrara,

Susan Geyer,

YF Liu,

Carmella EvansMolina,

Ingrid Libman,

Rachel Besser,

Dorothy Becker,

Henry Rodriguez,

Antoinette Moran,

Stephen E. Gitelman,

María J. Redondo

Publication year - 2017

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc16-2331

Subject(s) - medicine , diabetes mellitus , type 2 diabetes , type 1 diabetes , body mass index , risk factor , cohort , percentile , multivariate analysis , endocrinology , statistics , mathematics

OBJECTIVE We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk. RESULTS Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. CONCLUSIONS Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.

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