Predictive Properties of Biomarkers GDF-15, NTproBNP, and hs-TnT for Morbidity and Mortality in Patients With Type 2 Diabetes With Nephropathy | Zendy

Arash Bidadkosh | Zendy; Sebastiaan Lambooy | Zendy; Hiddo J.L. Heerspink | Zendy; Michelle J. Pena | Zendy; Robert H. Henning | Zendy; Hendrik Buikema | Zendy; Leo E. Deelman | Zendy

Open Access

Predictive Properties of Biomarkers GDF-15, NTproBNP, and hs-TnT for Morbidity and Mortality in Patients With Type 2 Diabetes With Nephropathy

Author(s) -

Arash Bidadkosh,

Sebastiaan Lambooy,

Hiddo J.L. Heerspink,

Michelle J. Pena,

Robert H. Henning,

Hendrik Buikema,

Leo E. Deelman

Publication year - 2017

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc16-2175

Subject(s) - medicine , renal function , hazard ratio , creatinine , biomarker , nephropathy , interquartile range , type 2 diabetes , endocrinology , kidney disease , natriuretic peptide , diabetes mellitus , proportional hazards model , urology , gastroenterology , heart failure , confidence interval , biochemistry , chemistry

Although patients with type 2 diabetes (T2D) with nephropathy are at high risk for renal and cardiovascular complications, relevant biomarkers have been poorly identified. Because renal impairment may increase biomarker levels, this potentially confounds associations between biomarker levels and risk. To investigate the predictive value of a biomarker in such a setting, we examined baseline levels of growth differentiation factor-15 (GDF-15), N-terminal prohormone of B-type natriuretic peptide (NTproBNP), and high-sensitivity troponin T (hs-TnT) in relation to renal and cardiovascular risk in T2D patients with nephropathy.

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