Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues | Zendy

Jennifer S. ten Kulve | Zendy; Dick J. Veltman | Zendy; Victor E. A. Gerdes | Zendy; Liselotte van Bloemendaal | Zendy; Frederik Barkhof | Zendy; Carolyn F. Deacon | Zendy; Jens J. Holst | Zendy; Madeleine L. Drent | Zendy; Michaëla Diamant | Zendy; Richard G. IJzerman | Zendy

Open Access

Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues

Author(s) -

Jennifer S. ten Kulve,

Dick J. Veltman,

Victor E. A. Gerdes,

Liselotte van Bloemendaal,

Frederik Barkhof,

Carolyn F. Deacon,

Jens J. Holst,

Madeleine L. Drent,

Michaëla Diamant,

Richard G. IJzerman

Publication year - 2017

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc16-2113

Subject(s) - medicine , appetite , glucagon like peptide 1 , endocrinology , peptide yy , blockade , ingestion , receptor , neuropeptide y receptor , neuropeptide , type 2 diabetes , diabetes mellitus

It has been suggested that weight reduction and improvements in satiety after Roux-en-Y gastric bypass (RYGB) are partly mediated via postoperative neuroendocrine changes. Glucagon-like peptide-1 (GLP-1) is a gut hormone secreted after food ingestion and is associated with appetite and weight reduction, mediated via effects on the central nervous system (CNS). Secretion of GLP-1 is greatly enhanced after RYGB. We hypothesized that postoperative elevated GLP-1 levels contribute to the improved satiety regulation after RYGB via effects on the CNS.

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