Macronutrient Intake–Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial | Zendy

Yoriko Heianza | Zendy; Wenjie Ma | Zendy; Tao Huang | Zendy; Tiange Wang | Zendy; Yan Zheng | Zendy; Steven R. Smith | Zendy; George A. Bray | Zendy; Frank M. Sacks | Zendy; Lu Qi | Zendy

Open Access

Macronutrient Intake–Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial

Author(s) -

Yoriko Heianza,

Wenjie Ma,

Tao Huang,

Tiange Wang,

Yan Zheng,

Steven R. Smith,

George A. Bray,

Frank M. Sacks,

Lu Qi

Publication year - 2016

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc16-1111

Subject(s) - medicine , weight loss , diabetes mellitus , body weight , fgf21 , obesity , composition (language) , genotype , endocrinology , zoology , biology , genetics , linguistics , philosophy , receptor , fibroblast growth factor , gene

Fibroblast growth factor 21 (FGF21) is involved in the regulation of energy balance and adipose metabolism. Our previous genome-wide association study identified genetic variants in the FGF21 region associated with macronutrient intake preference. We investigated whether the FGF21 genotype modified effects of weight-loss diets varying in macronutrient intake on changes in adiposity in a 2-year randomized diet intervention trial.

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