GLP-1 Restores Altered Insulin and Glucagon Secretion in Posttransplantation Diabetes | Zendy

Thea Anine Strøm Halden | Zendy; Erlend Johannessen Egeland | Zendy; Anders Åsberg | Zendy; Anders Hartmann | Zendy; Karsten Midtvedt | Zendy; Hassan Z. Khiabani | Zendy; Jens J. Holst | Zendy; Filip K. Knop | Zendy; Mads Hornum | Zendy; Bo FeldtRasmussen | Zendy; Trond Jenssen | Zendy

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GLP-1 Restores Altered Insulin and Glucagon Secretion in Posttransplantation Diabetes

Author(s) -

Thea Anine Strøm Halden,

Erlend Johannessen Egeland,

Anders Åsberg,

Anders Hartmann,

Karsten Midtvedt,

Hassan Z. Khiabani,

Jens J. Holst,

Filip K. Knop,

Mads Hornum,

Bo FeldtRasmussen,

Trond Jenssen

Publication year - 2016

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc15-2383

Subject(s) - medicine , endocrinology , glucagon , insulin , diabetes mellitus , arginine , bolus (digestion) , proinsulin , pancreatic hormone , glucose clamp technique , hyperglucagonemia , incretin , clamp , type 2 diabetes , insulin resistance , biology , amino acid , biochemistry , mechanical engineering , clamping , engineering

Development of posttransplantation diabetes (PTDM) is characterized by reduced insulin secretion and sensitivity. We aimed to investigate whether hyperglucagonemia could play a role in PTDM and to examine the insulinotropic and glucagonostatic effects of the incretin hormone glucagon-like peptide 1 (GLP-1) during fasting and hyperglycemic conditions, respectively.

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