Branched-Chain Amino Acids and Insulin Metabolism: The Insulin Resistance Atherosclerosis Study (IRAS) | Zendy

C. Christine Lee | Zendy; Steve M. Watkins | Zendy; Carlos Lorenzo | Zendy; Lynne E. Wagenknecht | Zendy; Dora Il’yasova | Zendy; Yii-Der I. Chen | Zendy; Steven M. Haffner | Zendy; Anthony J. Hanley | Zendy

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Branched-Chain Amino Acids and Insulin Metabolism: The Insulin Resistance Atherosclerosis Study (IRAS)

Author(s) -

C. Christine Lee,

Steve M. Watkins,

Carlos Lorenzo,

Lynne E. Wagenknecht,

Dora Il’yasova,

Yii-Der I. Chen,

Steven M. Haffner,

Anthony J. Hanley

Publication year - 2016

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc15-2284

Subject(s) - medicine , insulin resistance , endocrinology , diabetes mellitus , insulin , valine , odds ratio , confounding , amino acid , biology , biochemistry

Recent studies using untargeted metabolomics approaches have suggested that plasma branched-chain amino acids (BCAAs) are associated with incident diabetes. However, little is known about the role of plasma BCAAs in metabolic abnormalities underlying diabetes and whether these relationships are consistent across ethnic populations at high risk for diabetes. We investigated the associations of BCAAs with insulin sensitivity (SI), acute insulin response (AIR), and metabolic clearance of insulin (MCRI) in a multiethnic cohort.

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