Defining Pathways for Development of Disease-Modifying Therapies in Children With Type 1 Diabetes: A Consensus Report | Zendy

Diane K. Wherrett | Zendy; Jane L. Chiang | Zendy; Alan M. Delamater | Zendy; Linda A. DiMeglio | Zendy; Stephen E. Gitelman | Zendy; Peter A. Gottlieb | Zendy; Kevan C. Herold | Zendy; Daniel J. Lovell | Zendy; Trevor J. Orchard | Zendy; Christopher M. Ryan | Zendy; Desmond Schatz | Zendy; David Wendler | Zendy; Carla J. Greenbaum | Zendy

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Defining Pathways for Development of Disease-Modifying Therapies in Children With Type 1 Diabetes: A Consensus Report

Author(s) -

Diane K. Wherrett,

Jane L. Chiang,

Alan M. Delamater,

Linda A. DiMeglio,

Stephen E. Gitelman,

Peter A. Gottlieb,

Kevan C. Herold,

Daniel J. Lovell,

Trevor J. Orchard,

Christopher M. Ryan,

Desmond Schatz,

David Wendler,

Carla J. Greenbaum

Publication year - 2015

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc15-1429

Subject(s) - medicine , disease , type 2 diabetes , diabetes mellitus , type 1 diabetes , complex disease , medline , bioinformatics , intensive care medicine , endocrinology , political science , law , biology

Emerging data suggest that type 1 diabetes is a more aggressive disease in children than in adults, with important differences in pathophysiology and clinical course. Therefore, the efficacy of disease-modifying therapies may be different in the two populations. Understanding the developmental and regulatory pathways for type 1 diabetes-modifying therapies in children will enable industry, academia, funders, advocacy groups, and regulators to translate new science to clinical care. This consensus report characterizes the fundamental differences in type 1 diabetes between children and adults and proposes a thoughtful approach to better understand the development and regulatory pathways for type 1 diabetes therapies.

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