Insulin Dose and Cardiovascular Mortality in the ACCORD Trial | Zendy

Elias S. Siraj | Zendy; Daniel J. Rubin | Zendy; Matthew C. Riddle | Zendy; Michael E. Miller | Zendy; FangChi Hsu | Zendy; Faramarz IsmailBeigi | Zendy; Shyh-Huei Chen | Zendy; Walter T. Ambrosius | Zendy; Abraham Thomas | Zendy; William H. Bestermann | Zendy; John B. Buse | Zendy; Saul Genuth | Zendy; Carol Joyce | Zendy; Christopher S. Kovacs | Zendy; Patrick J. O’Connor | Zendy; Ronald J. Sigal | Zendy; Sol Solomon | Zendy

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Insulin Dose and Cardiovascular Mortality in the ACCORD Trial

Author(s) -

Elias S. Siraj,

Daniel J. Rubin,

Matthew C. Riddle,

Michael E. Miller,

FangChi Hsu,

Faramarz IsmailBeigi,

Shyh-Huei Chen,

Walter T. Ambrosius,

Abraham Thomas,

William H. Bestermann,

John B. Buse,

Saul Genuth,

Carol Joyce,

Christopher S. Kovacs,

Patrick J. O’Connor,

Ronald J. Sigal,

Sol Solomon

Publication year - 2015

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc15-0598

Subject(s) - medicine , insulin , hypoglycemia , hazard ratio , diabetes mellitus , proportional hazards model , basal (medicine) , type 2 diabetes , randomized controlled trial , endocrinology , confidence interval

In the ACCORD trial, intensive treatment of patients with type 2 diabetes and high cardiovascular (CV) risk was associated with higher all-cause and CV mortality. Post hoc analyses have failed to implicate rapid reduction of glucose, hypoglycemia, or specific drugs as the causes of this finding. We hypothesized that exposure to injected insulin was quantitatively associated with increased CV mortality.

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