Open AccessCardiovascular Disease Protection in Long-Duration Type 1 Diabetes and Sex Differences
Author(s) -
Zhiheng H. He,
Stephanie D’Eon,
Liane J. Tinsley,
Shane Fitzgerald,
Stephanie Hastings,
Mogher Khamaisi,
Jennifer K. Sun,
Sara J. Turek,
Ernst J. Schaefer,
George L. King,
Hillary A. Keenan
Publication year - 2015
Publication title -
diabetes care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.636
H-Index - 363
eISSN - 1935-5548
pISSN - 0149-5992
DOI - 10.2337/dc15-0017
Subject(s) - medicine , diabetes mellitus , type 2 diabetes , disease , medical record , demography , pediatrics , gerontology , endocrinology , sociology
Two recent articles describe higher morbidity and mortality from cardiovascular disease (CVD) at younger ages for women with type 1 diabetes compared with men in cohorts with average duration of approximately 30 years (1,2). Women in the Joslin 50-Year Medalist Study (total n = 680) have a significantly lower CVD prevalence than men (women 35.3% vs. men 51.6%, P < 0.001), suggesting a protective factor. The objective of this analysis was to investigate protective factors associated with CVD and sex-associated differences in rates in those with long-term type 1 diabetes.The Joslin 50-Year Medalist Study is a cross-sectional study of individuals with 50 or more years of type 1 diabetes ( n = 651). To be awarded the Joslin 50-Year Medal, individuals provide an original medical record from time of diagnosis, or three other forms of documentation of insulin dependence since the time of diagnosis 50 or more …
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