Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans | Zendy

Antigoni Z. Lalia | Zendy; Matthew L. Johnson | Zendy; Michael D. Jensen | Zendy; Kazanna C. Hames | Zendy; John D. Port | Zendy; Ian R. Lanza | Zendy

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Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans

Author(s) -

Antigoni Z. Lalia,

Matthew L. Johnson,

Michael D. Jensen,

Kazanna C. Hames,

John D. Port,

Ian R. Lanza

Publication year - 2015

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc14-3101

Subject(s) - medicine , endocrinology , insulin , insulin resistance , postprandial , docosahexaenoic acid , glucose uptake , type 2 diabetes , glucose clamp technique , diabetes mellitus , pancreatic hormone , polyunsaturated fatty acid , fatty acid , biology , biochemistry

Dietary n-3 polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), prevent insulin resistance and stimulate mitochondrial biogenesis in rodents, but the findings of translational studies in humans are thus far ambiguous. The aim of this study was to evaluate the influence of EPA and DHA on insulin sensitivity, insulin secretion, and muscle mitochondrial function in insulin-resistant, nondiabetic humans using a robust study design and gold-standard measurements.

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