Latent Autoimmune Diabetes in Stiff-Person Syndrome

GAD antibody (GADA) positivity is a hallmark of autoimmune diabetes and the rare autoimmune neurological disorder Stiff-Person Syndrome (SPS). Concomitant SPS and classical type 1 diabetes (T1D) have been described in case reports (1–3). A recent series of SPS reported the prevalence of T1D at 43% (4). However, the presence of alternative forms of autoimmune diabetes, such as latent autoimmune diabetes in adults (LADA) in SPS, is not well described. We report on two cases of SPS and LADA.A 72-year-old woman presented unable to walk after a 6-month history of progressive right leg stiffness, light touch–induced foot spasms, and pain. Examination revealed her right foot was plantarflexed and inverted with no active or …