Insulin Sensitivity Is an Important Determinant of Renal Health in Adolescents With Type 2 Diabetes | Zendy

Petter Bjornstad | Zendy; David M. Maahs | Zendy; David Z.I. Cherney | Zendy; Melanie CreeGreen | Zendy; Amy D. West | Zendy; Laura Pyle | Zendy; Kristen J. Nadeau | Zendy

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Insulin Sensitivity Is an Important Determinant of Renal Health in Adolescents With Type 2 Diabetes

Author(s) -

Petter Bjornstad,

David M. Maahs,

David Z.I. Cherney,

Melanie CreeGreen,

Amy D. West,

Laura Pyle,

Kristen J. Nadeau

Publication year - 2014

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc14-1331

Subject(s) - medicine , diabetes mellitus , type 2 diabetes , insulin sensitivity , endocrinology , type 1 diabetes , insulin , insulin resistance

Diabetic nephropathy (DN) remains the most common cause of end-stage renal disease and is a major cause of mortality in type 2 diabetes. Insulin sensitivity is an important determinant of renal health in adults with type 2 diabetes, but limited data exist in adolescents. We hypothesized that measured insulin sensitivity (glucose infusion rate [GIR]) would be associated with early markers of DN reflected by estimated glomerular filtration rate (eGFR) and albumin-creatinine ratio (ACR) in adolescents with type 2 diabetes.

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