Open AccessQuantification of the Glycemic Response to Microdoses of Subcutaneous Glucagon at Varying Insulin Levels
Author(s) -
Joseph El Youssef,
Jessica R. Castle,
Parkash A. Bakhtiani,
Ahmad Haidar,
Deborah Branigan,
Matthew Breen,
W. Kenneth Ward
Publication year - 2014
Publication title -
diabetes care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.636
H-Index - 363
eISSN - 1935-5548
pISSN - 0149-5992
DOI - 10.2337/dc14-0803
Subject(s) - medicine , glycemic , glucagon , diabetes mellitus , insulin , endocrinology
Glucagon delivery in closed-loop control of type 1 diabetes is effective in minimizing hypoglycemia. However, high insulin concentration lowers the hyperglycemic effect of glucagon, and small doses of glucagon in this setting are ineffective. There are no studies clearly defining the relationship between insulin levels, subcutaneous glucagon, and blood glucose.
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