Effect of 8 Weeks of Overfeeding on Ectopic Fat Deposition and Insulin Sensitivity: Testing the “Adipose Tissue Expandability” Hypothesis | Zendy

Darcy L. Johannsen | Zendy; Yourka D. Tchoukalova | Zendy; Charmaine S. Tam | Zendy; Jeffrey D. Covington | Zendy; Wenting Xie | Zendy; Jean-Marc Schwarz | Zendy; Sudip Bajpeyi | Zendy; Éric Ravussin | Zendy

Open Access

Effect of 8 Weeks of Overfeeding on Ectopic Fat Deposition and Insulin Sensitivity: Testing the “Adipose Tissue Expandability” Hypothesis

Author(s) -

Darcy L. Johannsen,

Yourka D. Tchoukalova,

Charmaine S. Tam,

Jeffrey D. Covington,

Wenting Xie,

Jean-Marc Schwarz,

Sudip Bajpeyi,

Éric Ravussin

Publication year - 2014

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc14-0761

Subject(s) - medicine , endocrinology , adipose tissue , insulin resistance , adipocyte , weight gain , skeletal muscle , insulin , glucose clamp technique , type 2 diabetes , obesity , diabetes mellitus , insulin sensitivity , body weight

The presence of large subcutaneous adipocytes in obesity has been proposed to be linked with insulin resistance and type 2 diabetes through the "adipose tissue expandability" hypothesis, which holds that large adipocytes have a limited capacity for expansion, forcing lipids to be stored in nonadipose ectopic depots (skeletal muscle, liver), where they interfere with insulin signaling. This hypothesis has, however, been largely formulated by cross-sectional findings and to date has not been prospectively demonstrated in the development of insulin resistance in humans.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research