Adjusting Glucose-Stimulated Insulin Secretion for Adipose Insulin Resistance: An Index of β-Cell Function in Obese Adults | Zendy

Steven K. Malin | Zendy; Sangeeta Kashyap | Zendy; Jeff Hammel | Zendy; Yoshi Miyazaki | Zendy; Ralph A. DeFronzo | Zendy; John P. Kirwan | Zendy

Open Access

Adjusting Glucose-Stimulated Insulin Secretion for Adipose Insulin Resistance: An Index of β-Cell Function in Obese Adults

Author(s) -

Steven K. Malin,

Sangeeta Kashyap,

Jeff Hammel,

Yoshi Miyazaki,

Ralph A. DeFronzo,

John P. Kirwan

Publication year - 2014

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc13-3011

Subject(s) - medicine , endocrinology , insulin resistance , adipose tissue , insulin , glucose uptake , obesity

The hyperbolic relationship between insulin secretion and sensitivity has been used to assess in vivo β-cell function (i.e., the disposition index). The disposition index emphasizes the importance of taking into account both skeletal muscle and hepatic insulin resistance to depict insulin secretion. However, we propose that adipose tissue insulin resistance also needs to be accounted for when characterizing glucose-stimulated insulin secretion (GSIS) because elevated plasma free fatty acids (FFAs) impair β-cell function.

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