Migratory Activity of Circulating Mononuclear Cells Is Associated With Cardiovascular Mortality in Type 2 Diabetic Patients With Critical Limb Ischemia | Zendy

Gaia Spinetti | Zendy; Claudia Specchia | Zendy; Orazio Fortunato | Zendy; Elena Sangalli | Zendy; Giacomo Clerici | Zendy; Maurizio Caminiti | Zendy; Flavio Airoldi | Zendy; Sergio Losa | Zendy; Costanza Emanueli | Zendy; Ezio Faglia | Zendy; Paolo Madeddu | Zendy

Open Access

Migratory Activity of Circulating Mononuclear Cells Is Associated With Cardiovascular Mortality in Type 2 Diabetic Patients With Critical Limb Ischemia

Author(s) -

Gaia Spinetti,

Claudia Specchia,

Orazio Fortunato,

Elena Sangalli,

Giacomo Clerici,

Maurizio Caminiti,

Flavio Airoldi,

Sergio Losa,

Costanza Emanueli,

Ezio Faglia,

Paolo Madeddu

Publication year - 2014

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc13-2084

Subject(s) - medicine , interquartile range , hazard ratio , critical limb ischemia , diabetes mellitus , myocardial infarction , proportional hazards model , cardiology , type 2 diabetes , prospective cohort study , amputation , surgery , endocrinology , revascularization , confidence interval

Prediction of clinical outcome in diabetic patients with critical limb ischemia (CLI) is unsatisfactory. This prospective study investigates if the abundance and migratory activity of a subpopulation of circulating mononuclear cells, namely, CD45(dim)CD34(pos)CXCR4(pos)KDR(pos) cells, predict major amputation and cardiovascular death in type 2 diabetic patients undergoing percutaneous transluminal angioplasty for CLI.

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